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    NTRK2 neurotrophic receptor tyrosine kinase 2 [ Gallus gallus (chicken) ]

    Gene ID: 396157, updated on 3-Dec-2024

    Summary

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    Symbol
    NTRK2provided by CGNC
    Full Name
    neurotrophic receptor tyrosine kinase 2provided by CGNC
    Primary source
    CGNC:49676
    See related
    Ensembl:ENSGALG00010010150
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    TRKB
    Orthologs
    human mouse all
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    Genomic context

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    See NTRK2 in Genome Data Viewer
    Location:
    chromosome: Z
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (40896675..41106926)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (40896675..41106926)

    Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121108594 Neighboring gene uncharacterized LOC121108595 Neighboring gene solute carrier family 28 member 3 Neighboring gene uncharacterized LOC124417557 Neighboring gene uncharacterized LOC121108596 Neighboring gene microRNA 7439

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TrkB downregulation is required for dendrite retraction in developing neurons of chicken nucleus magnocellularis. Schecterson LC, et al. J Neurosci, 2012 Oct 3. PMID 23035107, Free PMC Article
    2. Expression of TrkB receptor isoforms in the developing avian visual system. Garner AS, et al. J Neurosci, 1996 Mar 1. PMID 8774442, Free PMC Article
    3. Expression and binding characteristics of the BDNF receptor chick trkB. Dechant G, et al. Development, 1993 Oct. PMID 8287802
    4. Cloning and sequence analysis of a cDNA encoding a novel truncated form of the chicken TrkB receptor. Vinh NQ, et al. Gene, 1994 Nov 18. PMID 7959025
    5. TrkB/BDNF signalling patterns the sympathetic nervous system. Kasemeier-Kulesa JC, et al. Nat Commun, 2015 Sep 25. PMID 26404565, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BDNF released by preganglionic axons acts chemotactically on TrkB-positive sympathetic neurons, to pattern the developing peripheral nervous system.
      Title: TrkB/BDNF signalling patterns the sympathetic nervous system.
    2. Cessation of TrkB expression is essential for dendrite retraction and functional maturation of nucleus magnocellularis neurons.
      Title: TrkB downregulation is required for dendrite retraction in developing neurons of chicken nucleus magnocellularis.
    3. These results suggest that BDNF promotes the induction of imprinting through TrkB exclusively during the critical period.
      Title: Elevated expression of brain-derived neurotrophic factor facilitates visual imprinting in chicks.
    4. Activation of BDNF/TrkB signaling in the intermediate medial hyperpallium apicale is not involved in memory acquisition in filial imprinting in newly hatched chicks.
      Title: Activation of brain-derived neurotrophic factor/tropomyosin-related kinase B signaling accompanying filial imprinting in domestic chicks (Gallus gallus domesticus).
    5. Data support the hypothesis that a fine-tuned interplay of ephrinA6 with p75(NTR) and TrkB is important for the guidance and branching of RGC axons.
      Title: EphrinA6 on chick retinal axons is a key component for p75(NTR)-dependent axon repulsion and TrkB-dependent axon branching.
    6. The ephrinA/TrkB Interaction is neurotrophin induced and specifically augments the PI-3 kinase/Akt pathway generally known to be involved in the promotion of branching.
      Title: A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis.
    7. elevated BDNF expression above basal levels and signaling through TrkB in sympathoblasts may be a mechanism that contributes to the onset of neuroblastoma
      Title: Embryonic sympathoblasts transiently express TrkB in vivo and proliferate in response to brain-derived neurotrophic factor in vitro.
    8. findings demonstrate roles for BDNF-induced, trk-dependent signaling in ciliary ganglion neurons, both in regulating expression of alpha7-nAChRs and in enhancing transmission at alpha3*-nAChR-mediated synapses
      Title: Brain-derived neurotrophic factor and trkB signaling in parasympathetic neurons: relevance to regulating alpha7-containing nicotinic receptors and synaptic function.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables axon guidance receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables brain-derived neurotrophic factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables brain-derived neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to brain-derived neurotrophic factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synapse organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in trans-synaptic signaling by neuropeptide, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BDNF/NT-3 growth factors receptor
    Names
    neurotrophic tyrosine kinase, receptor, type 2
    trk-B
    trkB tyrosine kinase
    tyrosine kinase receptor
    NP_990562.2
    XP_015135735.2
    XP_015135739.2
    XP_015135740.2
    XP_015135741.2
    XP_015135742.2
    XP_015135743.2
    XP_025000452.2
    XP_046790807.1
    XP_046790808.1
    XP_046790809.1
    XP_046790810.1
    XP_046790811.1
    XP_046790812.1
    XP_046790813.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205231.2 → NP_990562.2  BDNF/NT-3 growth factors receptor precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000094
      UniProtKB/Swiss-Prot
      Q91010, Q91987
      UniProtKB/TrEMBL
      A0A8V0XZQ5
      Related
      ENSGALP00010013790.1, ENSGALT00010024225.1
      Conserved Domains (2) summary
      smart00409
      Location:204 → 282
      IG; Immunoglobulin
      cd05093
      Location:528 → 815
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      40896675..41106926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015280249.4 → XP_015135735.2  BDNF/NT-3 growth factors receptor isoform X1

      UniProtKB/Swiss-Prot
      Q91010, Q91987
      UniProtKB/TrEMBL
      A0A8V0YCV8
      Related
      ENSGALP00010013786.1, ENSGALT00010024215.1
      Conserved Domains (3) summary
      smart00409
      Location:204 → 282
      IG; Immunoglobulin
      cd05093
      Location:552 → 839
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      sd00031
      Location:67 → 94
      LRR_1; leucine-rich repeat [structural motif]

    2. XM_015280253.4 → XP_015135739.2  BDNF/NT-3 growth factors receptor isoform X2

      UniProtKB/TrEMBL
      A0A8V0XZL6
      Conserved Domains (5) summary
      smart00409
      Location:204 → 282
      IG; Immunoglobulin
      sd00031
      Location:67 → 94
      LRR_1; leucine-rich repeat [structural motif]
      cd00096
      Location:312 → 318
      Ig; Ig strand C [structural motif]
      cl11960
      Location:306 → 377
      Ig; Immunoglobulin domain
      cl15307
      Location:147 → 194
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    3. XM_025144684.3 → XP_025000452.2  BDNF/NT-3 growth factors receptor isoform X3

      UniProtKB/TrEMBL
      A0A8V0XZL6
      Conserved Domains (5) summary
      smart00409
      Location:204 → 282
      IG; Immunoglobulin
      sd00031
      Location:67 → 94
      LRR_1; leucine-rich repeat [structural motif]
      cd00096
      Location:312 → 318
      Ig; Ig strand C [structural motif]
      cl11960
      Location:306 → 377
      Ig; Immunoglobulin domain
      cl15307
      Location:147 → 194
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    4. XM_015280254.4 → XP_015135740.2  BDNF/NT-3 growth factors receptor isoform X4

      UniProtKB/TrEMBL
      A0A8V0XZL6, A0A8V0Y475
      Related
      ENSGALP00010013759.1, ENSGALT00010024159.1
      Conserved Domains (5) summary
      smart00409
      Location:204 → 282
      IG; Immunoglobulin
      sd00031
      Location:67 → 94
      LRR_1; leucine-rich repeat [structural motif]
      cd00096
      Location:312 → 318
      Ig; Ig strand C [structural motif]
      cl11960
      Location:306 → 377
      Ig; Immunoglobulin domain
      cl15307
      Location:147 → 194
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    5. XM_015280255.4 → XP_015135741.2  BDNF/NT-3 growth factors receptor isoform X5

      UniProtKB/TrEMBL
      A0A8V0XZL6, A0A8V0Y851
      Related
      ENSGALP00010013768.1, ENSGALT00010024177.1
      Conserved Domains (5) summary
      smart00409
      Location:204 → 282
      IG; Immunoglobulin
      sd00031
      Location:67 → 94
      LRR_1; leucine-rich repeat [structural motif]
      cd00096
      Location:313 → 317
      Ig; Ig strand C [structural motif]
      cl11960
      Location:306 → 377
      Ig; Immunoglobulin domain
      cl15307
      Location:147 → 194
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    6. XM_015280256.4 → XP_015135742.2  BDNF/NT-3 growth factors receptor isoform X6

      UniProtKB/TrEMBL
      A0A8V0XZL6, A0A8V0Y846
      Related
      ENSGALP00010013763.1, ENSGALT00010024165.1
      Conserved Domains (5) summary
      smart00409
      Location:204 → 282
      IG; Immunoglobulin
      sd00031
      Location:67 → 94
      LRR_1; leucine-rich repeat [structural motif]
      cd00096
      Location:312 → 318
      Ig; Ig strand C [structural motif]
      cl11960
      Location:306 → 377
      Ig; Immunoglobulin domain
      cl15307
      Location:147 → 194
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    7. XM_015280257.4 → XP_015135743.2  BDNF/NT-3 growth factors receptor isoform X7

      UniProtKB/TrEMBL
      A0A8V0XZL6
      Related
      ENSGALP00010013750.1, ENSGALT00010024145.1
      Conserved Domains (5) summary
      smart00409
      Location:204 → 282
      IG; Immunoglobulin
      sd00031
      Location:67 → 94
      LRR_1; leucine-rich repeat [structural motif]
      cd00096
      Location:312 → 318
      Ig; Ig strand C [structural motif]
      cl11960
      Location:306 → 377
      Ig; Immunoglobulin domain
      cl15307
      Location:147 → 194
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      40896675..41106926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046934851.1 → XP_046790807.1  BDNF/NT-3 growth factors receptor isoform X1

      UniProtKB/Swiss-Prot
      Q91010, Q91987
      UniProtKB/TrEMBL
      A0A8V0YCV8

    2. XM_046934852.1 → XP_046790808.1  BDNF/NT-3 growth factors receptor isoform X2

      UniProtKB/TrEMBL
      A0A8V0XZL6

    3. XM_046934853.1 → XP_046790809.1  BDNF/NT-3 growth factors receptor isoform X3

      UniProtKB/TrEMBL
      A0A8V0XZL6

    4. XM_046934854.1 → XP_046790810.1  BDNF/NT-3 growth factors receptor isoform X4

      UniProtKB/TrEMBL
      A0A8V0XZL6, A0A8V0Y475

    5. XM_046934855.1 → XP_046790811.1  BDNF/NT-3 growth factors receptor isoform X5

      UniProtKB/TrEMBL
      A0A8V0XZL6, A0A8V0Y851

    6. XM_046934856.1 → XP_046790812.1  BDNF/NT-3 growth factors receptor isoform X6

      UniProtKB/TrEMBL
      A0A8V0XZL6, A0A8V0Y846

    7. XM_046934857.1 → XP_046790813.1  BDNF/NT-3 growth factors receptor isoform X7

      UniProtKB/TrEMBL
      A0A8V0XZL6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91987.1 GenPept UniProtKB/Swiss-Prot:Q91987

    Gene LinkOut

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