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    GRM5 glutamate receptor, metabotropic 5 [ Gallus gallus (chicken) ]

    Gene ID: 373933, updated on 17-Aug-2024

    Summary

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    Official Symbol
    GRM5provided by CGNC
    Official Full Name
    glutamate receptor, metabotropic 5provided by CGNC
    Primary source
    CGNC:48964
    See related
    Ensembl:ENSGALG00010007886
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See GRM5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (187842732..188097684)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (187872966..188127444)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121107447 Neighboring gene uncharacterized LOC121107448 Neighboring gene tyrosinase Neighboring gene uncharacterized LOC121107450 Neighboring gene cathepsin C Neighboring gene RAB38, member RAS oncogene family Neighboring gene microRNA 1657

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metabotropic glutamate receptor 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001397865.1 → NP_001384794.1  metabotropic glutamate receptor 5 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000027
      UniProtKB/TrEMBL
      A0A1D5PH56, Q98UC5
      Related
      ENSGALP00010010312.1, ENSGALT00010018762.1
      Conserved Domains (4) summary
      cd15450
      Location:584 → 833
      7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06374
      Location:32 → 503
      PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
      pfam07562
      Location:514 → 564
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      pfam10606
      Location:1139 → 1188
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

    2. NM_001397866.1 → NP_001384795.1  metabotropic glutamate receptor 5 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000027
      UniProtKB/TrEMBL
      A0A1D5PVJ3, Q98UC6
      Related
      ENSGALP00010010313.1, ENSGALT00010018763.1
      Conserved Domains (4) summary
      cd15450
      Location:584 → 833
      7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06374
      Location:32 → 503
      PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
      pfam07562
      Location:514 → 564
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      pfam10606
      Location:1107 → 1156
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

    3. NM_204138.2 → NP_989469.2  metabotropic glutamate receptor 5 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000027
      UniProtKB/TrEMBL
      F1NWG3
      Related
      ENSGALP00010010310.1, ENSGALT00010018760.1
      Conserved Domains (4) summary
      cd15450
      Location:584 → 833
      7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06374
      Location:32 → 503
      PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
      pfam07562
      Location:514 → 564
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      pfam10606
      Location:1193 → 1242
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      187842732..188097684
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015279791.4 → XP_015135277.1  metabotropic glutamate receptor 5 isoform X1

      UniProtKB/TrEMBL
      F1NWG3
      Conserved Domains (4) summary
      cd15450
      Location:584 → 833
      7tmC_mGluR5; metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06374
      Location:32 → 503
      PBP1_mGluR_groupI; ligand binding domain of the group I metabotropic glutamate receptor
      pfam07562
      Location:514 → 564
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      pfam10606
      Location:1193 → 1242
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      187872966..188127444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046906295.1 → XP_046762251.1  metabotropic glutamate receptor 5 isoform X1

      UniProtKB/TrEMBL
      Q98UC4
    Nucleotide Protein
    Heading Accession and Version

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