TLR7 toll like receptor 7 [Gallus gallus (chicken)] - Gene

Summary

Symbol: TLR7provided by CGNC
Full Name: toll like receptor 7provided by CGNC
Primary source: CGNC:12429
See related: Ensembl:ENSGALG00010001897
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (123561394..123568153, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (123522887..123529646, complement)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Infectious bronchitis virus inhibits activation of the TLR7 pathway, but not the TLR3 pathway.
Title: Infectious bronchitis virus inhibits activation of the TLR7 pathway, but not the TLR3 pathway.
results showed that activation of TLR7 is associated with anorexia, hypoactivity, hypothermia, disturbance of feed passage in the digestive tract and the response to stress in chicks
Title: Effects of toll-like receptor-7 agonists on feeding behaviour, voluntary activity, cloacal temperature and crop emptying in chicks.
Antiviral response elicited against avian influenza virus infection following activation of TLR7 signaling pathway is attributable to interleukin IL-1beta production.
Title: Antiviral response elicited against avian influenza virus infection following activation of toll-like receptor (TLR)7 signaling pathway is attributable to interleukin (IL)-1β production.
Results show that the Toll-like receptors TLR4 and TLR7 that the mRNA expression levels in the spleen were lower in the 300, 600, and 900 mg/kg groups than those in the control group.
Title: Downregulation of TLR4 and 7 mRNA expression levels in broiler's spleen caused by diets supplemented with nickel chloride.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables pattern recognition receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in toll-like receptor 7 signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: toll-like receptor 7

Names: toll-like receptor 7-long

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011688.3 → NP_001011688.2 toll-like receptor 7

Status: VALIDATED

Source sequence(s)

AJ720504, AJ740367, JAENSK010000024, KM486600, KM486601

UniProtKB/TrEMBL

A0A0A7M9V8, A0A0A7MEX8, A0A1L4FMI1, A0A1L4FMK6, A0A1L4FML6

Related

ENSGALP00010002615.1, ENSGALT00010004337.1

Conserved Domains (6) summary

PRK15370
Location:40 → 196

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:763 → 849

PCC; polycystin cation channel protein

smart00255
Location:900 → 1044

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:131 → 721

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:137 → 156

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:709 → 769

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

123561394..123568153 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015273651.4 → XP_015129137.2 toll-like receptor 7 isoform X1

UniProtKB/TrEMBL

A0A8V0XDV1, Q5GQ97

Conserved Domains (5) summary

PRK15370
Location:32 → 188

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:755 → 841

PCC; polycystin cation channel protein

smart00255
Location:892 → 1036

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:123 → 713

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:129 → 148

LRR_RI; leucine-rich repeat [structural motif]
XM_015273642.4 → XP_015129128.2 toll-like receptor 7 isoform X1

UniProtKB/TrEMBL

A0A8V0XDV1, Q5GQ97

Conserved Domains (5) summary

PRK15370
Location:32 → 188

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:755 → 841

PCC; polycystin cation channel protein

smart00255
Location:892 → 1036

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:123 → 713

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:129 → 148

LRR_RI; leucine-rich repeat [structural motif]
XM_015273647.4 → XP_015129133.2 toll-like receptor 7 isoform X1

UniProtKB/TrEMBL

A0A8V0XDV1, Q5GQ97

Related

ENSGALP00010002613.1, ENSGALT00010004335.1

Conserved Domains (5) summary

PRK15370
Location:32 → 188

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:755 → 841

PCC; polycystin cation channel protein

smart00255
Location:892 → 1036

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:123 → 713

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:129 → 148

LRR_RI; leucine-rich repeat [structural motif]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

123522887..123529646 complement

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GenBank, FASTA, Sequence Viewer (Graphics)