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    NCK1 NCK adaptor protein 1 [ Gallus gallus (chicken) ]

    Gene ID: 418727, updated on 3-Dec-2024

    Summary

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    Symbol
    NCK1provided by CGNC
    Full Name
    NCK adaptor protein 1provided by CGNC
    Primary source
    CGNC:50836
    See related
    Ensembl:ENSGALG00010012944
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    NCK2
    Orthologs
    human mouse all
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    Genomic context

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    See NCK1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (135390801..135473859)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (135347861..135430882)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101751432 Neighboring gene uncharacterized LOC107051986 Neighboring gene uncharacterized LOC121106671 Neighboring gene uncharacterized LOC107051985 Neighboring gene C2orf40 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nck2 is essential for limb trajectory selection by spinal motor axons. Chang CJ, et al. Dev Dyn, 2018 Sep. PMID 30016580
    2. Splenic gene expression profiling in White Leghorn layer inoculated with the Salmonella enterica serovar Enteritidis. Wu G, et al. Anim Genet, 2015 Dec. PMID 26358731
    3. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of PERK-mediated unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of translation in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytoplasmic protein NCK2
    Names
    NCK adaptor protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030814.2 → NP_001025985.2  cytoplasmic protein NCK2

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000025
      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48
      Related
      ENSGALP00010018059.1, ENSGALT00010031063.1
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      135390801..135473859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046941053.1 → XP_046797009.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    2. XM_046941073.1 → XP_046797029.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    3. XM_040699199.2 → XP_040555133.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48
      Related
      ENSGALP00010018068.1, ENSGALT00010031073.1
      Conserved Domains (4) summary
      cd10409
      Location:283 → 380
      SH2_Nck2; Src homology 2 (SH2) domain found in Nck
      cd11899
      Location:2 → 59
      SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
      cd11902
      Location:114 → 168
      SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
      cd11903
      Location:198 → 256
      SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

    4. XM_046941063.1 → XP_046797019.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    5. XM_046941057.1 → XP_046797013.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    6. XM_046941077.1 → XP_046797033.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    7. XM_046941055.1 → XP_046797011.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    8. XM_046941065.1 → XP_046797021.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    9. XM_046941059.1 → XP_046797015.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    10. XM_046941060.1 → XP_046797016.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      135347861..135430882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046908072.1 → XP_046764028.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    2. XM_046908079.1 → XP_046764035.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    3. XM_046908073.1 → XP_046764029.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    4. XM_046908077.1 → XP_046764033.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    5. XM_046908075.1 → XP_046764031.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    6. XM_046908080.1 → XP_046764036.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    7. XM_046908074.1 → XP_046764030.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    8. XM_046908078.1 → XP_046764034.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48

    9. XM_046908076.1 → XP_046764032.1  cytoplasmic protein NCK2 isoform X1

      UniProtKB/TrEMBL
      F1P4Q4, Q5ZK48
    Nucleotide Protein Strain
    Heading Accession and Version

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