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    RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase [ Gallus gallus (chicken) ]

    Gene ID: 417529, updated on 3-Dec-2024

    Summary

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    Symbol
    RFFLprovided by CGNC
    Full Name
    ring finger and FYVE like domain containing E3 ubiquitin protein ligaseprovided by CGNC
    Primary source
    CGNC:1592
    See related
    Ensembl:ENSGALG00010029950
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See RFFL in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 19 NC_052550.1 (4965597..4989287)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 19 NC_052591.1 (4694032..4717710)

    Chromosome 19 - NC_052550.1Genomic Context describing neighboring genes Neighboring gene unc-45 myosin chaperone B Neighboring gene RAD51 paralog D Neighboring gene uncharacterized LOC121107263 Neighboring gene DNA ligase 3 Neighboring gene uncharacterized LOC101747457

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase rififylin
    Names
    ring finger and FYVE-like domain containing 1
    NP_001025882.1
    XP_015151208.1
    XP_015151209.1
    XP_015151211.1
    XP_024997718.1
    XP_040505998.1
    XP_046758310.1
    XP_046758311.1
    XP_046758312.1
    XP_046785992.1
    XP_046785993.1
    XP_046785994.1
    XP_046785995.1
    XP_046785996.1
    XP_046785997.1
    XP_046785998.1
    XP_046785999.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030711.2 → NP_001025882.1  E3 ubiquitin-protein ligase rififylin

      See identical proteins and their annotated locations for NP_001025882.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000323
      UniProtKB/TrEMBL
      A0A1D5PNA5, A0A8V1AFQ1, Q5ZI26
      Conserved Domains (2) summary
      cd15770
      Location:44 → 92
      FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
      cd16500
      Location:312 → 350
      RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052550.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      4965597..4989287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015295723.4 → XP_015151209.1  E3 ubiquitin-protein ligase rififylin isoform X1

      UniProtKB/TrEMBL
      A0A1D5PNA5, A0A8V1AFQ1, Q5ZI26
      Conserved Domains (2) summary
      cd15770
      Location:44 → 92
      FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
      cd16500
      Location:312 → 350
      RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

    2. XM_040650064.2 → XP_040505998.1  E3 ubiquitin-protein ligase rififylin isoform X2

      UniProtKB/TrEMBL
      A0A8V1AFQ1
      Conserved Domains (2) summary
      cd15770
      Location:44 → 92
      FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
      cd16500
      Location:284 → 322
      RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

    3. XM_015295722.4 → XP_015151208.1  E3 ubiquitin-protein ligase rififylin isoform X1

      UniProtKB/TrEMBL
      A0A1D5PNA5, A0A8V1AFQ1, Q5ZI26
      Related
      ENSGALP00010044848.1, ENSGALT00010072381.1
      Conserved Domains (2) summary
      cd15770
      Location:44 → 92
      FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
      cd16500
      Location:312 → 350
      RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

    4. XM_046902355.1 → XP_046758311.1  E3 ubiquitin-protein ligase rififylin isoform X1

      UniProtKB/TrEMBL
      A0A1D5PNA5, A0A8V1AFQ1, Q5ZI26

    5. XM_046902354.1 → XP_046758310.1  E3 ubiquitin-protein ligase rififylin isoform X1

      UniProtKB/TrEMBL
      A0A1D5PNA5, A0A8V1AFQ1, Q5ZI26

    6. XM_015295725.3 → XP_015151211.1  E3 ubiquitin-protein ligase rififylin isoform X1

      UniProtKB/TrEMBL
      A0A1D5PNA5, A0A8V1AFQ1, Q5ZI26
      Conserved Domains (2) summary
      cd15770
      Location:44 → 92
      FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
      cd16500
      Location:312 → 350
      RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

    7. XM_025141950.3 → XP_024997718.1  E3 ubiquitin-protein ligase rififylin isoform X2

      UniProtKB/TrEMBL
      A0A8V1AFQ1
      Conserved Domains (2) summary
      cd15770
      Location:44 → 92
      FYVE_CARP2; FYVE-like domain found in caspase regulator CARP2 and similar proteins
      cd16500
      Location:284 → 322
      RING-HC_CARP; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein CARP-1, CARP-2 and similar proteins

    8. XM_046902356.1 → XP_046758312.1  E3 ubiquitin-protein ligase rififylin isoform X1

      UniProtKB/TrEMBL
      A0A1D5PNA5, A0A8V1AFQ1, Q5ZI26

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052591.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      4694032..4717710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046930037.1 → XP_046785993.1  E3 ubiquitin-protein ligase rififylin isoform X1

      UniProtKB/TrEMBL
      A0A1D5PNA5, A0A8V1AFQ1, Q5ZI26

    2. XM_046930042.1 → XP_046785998.1  E3 ubiquitin-protein ligase rififylin isoform X2

      UniProtKB/TrEMBL
      A0A8V1AFQ1

    3. XM_046930036.1 → XP_046785992.1  E3 ubiquitin-protein ligase rififylin isoform X1

      UniProtKB/TrEMBL
      A0A1D5PNA5, A0A8V1AFQ1, Q5ZI26

    4. XM_046930040.1 → XP_046785996.1  E3 ubiquitin-protein ligase rififylin isoform X1

      UniProtKB/TrEMBL
      A0A1D5PNA5, A0A8V1AFQ1, Q5ZI26

    5. XM_046930038.1 → XP_046785994.1  E3 ubiquitin-protein ligase rififylin isoform X1

      UniProtKB/TrEMBL
      A0A1D5PNA5, A0A8V1AFQ1, Q5ZI26

    6. XM_046930039.1 → XP_046785995.1  E3 ubiquitin-protein ligase rififylin isoform X1

      UniProtKB/TrEMBL
      A0A1D5PNA5, A0A8V1AFQ1, Q5ZI26

    7. XM_046930043.1 → XP_046785999.1  E3 ubiquitin-protein ligase rififylin isoform X2

      UniProtKB/TrEMBL
      A0A8V1AFQ1

    8. XM_046930041.1 → XP_046785997.1  E3 ubiquitin-protein ligase rififylin isoform X1

      UniProtKB/TrEMBL
      A0A1D5PNA5, A0A8V1AFQ1, Q5ZI26
    Nucleotide Protein Strain
    Heading Accession and Version

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