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    DAG1 dystroglycan 1 [ Gallus gallus (chicken) ]

    Gene ID: 100049058, updated on 3-Dec-2024

    Summary

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    Symbol
    DAG1provided by CGNC
    Full Name
    dystroglycan 1provided by CGNC
    Primary source
    CGNC:59244
    See related
    Ensembl:ENSGALG00010027288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See DAG1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (2606092..2644943, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (2623542..2662369, complement)

    Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene T-cell leukemia translocation altered Neighboring gene aminomethyltransferase Neighboring gene nicolin 1 Neighboring gene macrophage stimulating 1 (hepatocyte growth factor-like) Neighboring gene acylaminoacyl-peptide hydrolase like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dystroglycan regulates structure, proliferation and differentiation of neuroepithelial cells in the developing vertebrate CNS. Schröder JE, et al. Dev Biol, 2007 Jul 1. PMID 17512925
    2. Aberrant glycosylation of alpha-dystroglycan causes defective binding of laminin in the muscle of chicken muscular dystrophy. Saito F, et al. FEBS Lett, 2005 Apr 25. PMID 15848172
    3. The effects of post-translational processing on dystroglycan synthesis and trafficking. Esapa CT, et al. FEBS Lett, 2003 Dec 4. PMID 14644417
    4. Agrin is a high-affinity binding protein of dystroglycan in non-muscle tissue. Gesemann M, et al. J Biol Chem, 1998 Jan 2. PMID 9417121
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. aberrant glycosylation of alpha-DG in the pathogenesis of muscular degeneration in this model animal of muscular dystrophy
      Title: Aberrant glycosylation of alpha-dystroglycan causes defective binding of laminin in the muscle of chicken muscular dystrophy.
    2. dystroglycan plays a key role in maintaining neuroepithelial cell morphology, and that interference with dystroglycan function influences proliferation and differentiation of neuroepithelial cells
      Title: Dystroglycan regulates structure, proliferation and differentiation of neuroepithelial cells in the developing vertebrate CNS.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables laminin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in muscle attachment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of dystroglycan complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of dystrophin-associated glycoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dystroglycan 1
    Names
    dystroglycan 1 (dystrophin-associated glycoprotein 1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001097540.2 → NP_001091009.2  dystroglycan 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000251
      UniProtKB/TrEMBL
      A0A8V1A8D4, A4VAR9
      Conserved Domains (3) summary
      cd11303
      Location:61 → 162
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      cd11305
      Location:180 → 303
      alpha_DG_C; C-terminal domain of alpha dystroglycan
      PRK14971
      Location:302 → 406
      PRK14971; DNA polymerase III subunit gamma/tau

    2. NM_001398255.1 → NP_001385184.1  dystroglycan 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000251
      UniProtKB/TrEMBL
      A0A8V1A8D4, A4VAR9
      Related
      ENSGALP00010040426.1, ENSGALT00010066160.1
      Conserved Domains (3) summary
      cd11303
      Location:61 → 162
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      cd11305
      Location:180 → 303
      alpha_DG_C; C-terminal domain of alpha dystroglycan
      PRK14971
      Location:302 → 406
      PRK14971; DNA polymerase III subunit gamma/tau

    3. NM_001398256.1 → NP_001385185.1  dystroglycan 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000251
      UniProtKB/TrEMBL
      A0A8V1A8D4, A4VAR9
      Conserved Domains (3) summary
      cd11303
      Location:61 → 162
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      cd11305
      Location:180 → 303
      alpha_DG_C; C-terminal domain of alpha dystroglycan
      PRK14971
      Location:302 → 406
      PRK14971; DNA polymerase III subunit gamma/tau

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      2606092..2644943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      2623542..2662369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials