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    Sumf2 sulfatase modifying factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 67902, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Sumf2provided by MGI
    Official Full Name
    sulfatase modifying factor 2provided by MGI
    Primary source
    MGI:MGI:1915152
    See related
    Ensembl:ENSMUSG00000025538 AllianceGenome:MGI:1915152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610040F05Rik
    Summary
    Enables identical protein binding activity. Predicted to be involved in negative regulation of post-translational protein modification. Is active in endoplasmic reticulum lumen. Orthologous to human SUMF2 (sulfatase modifying factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 11.6), ovary adult (RPKM 9.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sumf2 in Genome Data Viewer
    Location:
    5 G1.3; 5 68.26 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129875807..129892275)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129846990..129863951)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 6A Neighboring gene predicted gene, 23245 Neighboring gene STARR-positive B cell enhancer ABC_E3624 Neighboring gene small nucleolar RNA, H/ACA box 15 Neighboring gene phosphorylase kinase gamma 1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E125 Neighboring gene STARR-positive B cell enhancer ABC_E2766 Neighboring gene zinc finger BED-type containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2. Zito E, et al. EMBO Rep, 2005 Jul. PMID 15962010, Free PMC Article
    2. Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development. Uijtdewilligen PJE, et al. Biomed Res Int, 2018. PMID 30228991, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inactive C-alpha-formylglycine-generating enzyme 2
    Names
    C-alpha-formylglycine-generating enzyme 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417670.1 → NP_001404599.1  inactive C-alpha-formylglycine-generating enzyme 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC242408
      UniProtKB/TrEMBL
      Q3TM08

    2. NM_001417671.1 → NP_001404600.1  inactive C-alpha-formylglycine-generating enzyme 2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC242408
      UniProtKB/TrEMBL
      Q3TM08

    3. NM_001417672.1 → NP_001404601.1  inactive C-alpha-formylglycine-generating enzyme 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC242408
      UniProtKB/TrEMBL
      Q0VDW5

    4. NM_026445.3 → NP_080721.1  inactive C-alpha-formylglycine-generating enzyme 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080721.1

      Status: VALIDATED

      Source sequence(s)
      AC242408
      Consensus CDS
      CCDS19700.1
      UniProtKB/Swiss-Prot
      Q3TZL1, Q3UUL0, Q8BPG6, Q9CZ47
      UniProtKB/TrEMBL
      Q3TM08
      Related
      ENSMUSP00000126036.2, ENSMUST00000171300.8
      Conserved Domains (2) summary
      COG1262
      Location:36 → 302
      YfmG; Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain [Posttranslational modification, protein turnover, chaperones]
      pfam03781
      Location:36 → 298
      FGE-sulfatase; Sulfatase-modifying factor enzyme 1

    RNA

    1. NR_184559.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC242408

    2. NR_184560.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC242408
      Related
      ENSMUST00000137357.5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      129875807..129892275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165445.1 → XP_036021338.1  inactive C-alpha-formylglycine-generating enzyme 2 isoform X1

      Conserved Domains (1) summary
      pfam03781
      Location:36 → 233
      FGE-sulfatase; Sulfatase-modifying factor enzyme 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BPG6.2 GenPept UniProtKB/Swiss-Prot:Q8BPG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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