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    Uqcr10 ubiquinol-cytochrome c reductase, complex III subunit X [ Mus musculus (house mouse) ]

    Gene ID: 66152, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Uqcr10provided by MGI
    Official Full Name
    ubiquinol-cytochrome c reductase, complex III subunit Xprovided by MGI
    Primary source
    MGI:MGI:1913402
    See related
    Ensembl:ENSMUSG00000059534 AllianceGenome:MGI:1913402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ucrc; 1110020P15Rik
    Summary
    Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Part of respiratory chain complex III. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human UQCR10 (ubiquinol-cytochrome c reductase, complex III subunit X). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 398.9), heart adult (RPKM 307.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Uqcr10 in Genome Data Viewer
    Location:
    11 A1; 11 2.96 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4651968..4654344, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4701968..4704344, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11961 Neighboring gene STARR-positive B cell enhancer ABC_E3930 Neighboring gene activating signal cointegrator 1 complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_28397 Neighboring gene STARR-seq mESC enhancer starr_28398 Neighboring gene STARR-positive B cell enhancer ABC_E2979 Neighboring gene zinc finger, matrin type 5 Neighboring gene STARR-seq mESC enhancer starr_28401 Neighboring gene calcium binding protein 7 Neighboring gene predicted gene, 35102

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structure and assembly of the mammalian mitochondrial supercomplex CIII(2)CIV. Vercellino I, et al. Nature, 2021 Oct. PMID 34616041
    2. Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria. Schilling B, et al. Biochim Biophys Acta, 2006 Feb. PMID 16120479
    3. Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice. Inoue M, et al. Endocrinology, 2016 Mar. PMID 26697723
    4. RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. Poché RA, et al. Cell Rep, 2016 Feb 23. PMID 26876175, Free PMC Article
    5. Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment. Osipovich AB, et al. Genome Res, 2005 Mar. PMID 15741512, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cellular respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex III ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome b-c1 complex subunit 9
    Names
    complex III subunit 9
    complex III subunit X
    cytochrome c1 non-heme 7 kDa protein
    ubiquinol-cytochrome c reductase complex (7.2 kD)
    ubiquinol-cytochrome c reductase complex 7.2 kDa protein
    ubiquinol-cytochrome c reductase complex protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362879.1 → NP_001349808.1  cytochrome b-c1 complex subunit 9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606521
      Conserved Domains (1) summary
      pfam05365
      Location:10 → 54
      UCR_UQCRX_QCR9; Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like

    2. NM_197979.3 → NP_932096.1  cytochrome b-c1 complex subunit 9 isoform 1

      See identical proteins and their annotated locations for NP_932096.1

      Status: VALIDATED

      Source sequence(s)
      AW985484, BC100591, CB599515
      Consensus CDS
      CCDS36098.1
      UniProtKB/Swiss-Prot
      Q8R1I1
      UniProtKB/TrEMBL
      Q5NCJ9
      Related
      ENSMUSP00000054856.5, ENSMUST00000058407.6
      Conserved Domains (1) summary
      pfam05365
      Location:10 → 60
      UCR_UQCRX_QCR9; Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like

    RNA

    1. NR_156411.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL606521, AU258939
      Related
      ENSMUST00000151559.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      4651968..4654344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047158.1: Suppressed sequence

      Description
      NM_001047158.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1I1.1 GenPept UniProtKB/Swiss-Prot:Q8R1I1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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