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    Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 16519, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Kcnj3provided by MGI
    Official Full Name
    potassium inwardly-rectifying channel, subfamily J, member 3provided by MGI
    Primary source
    MGI:MGI:104742
    See related
    Ensembl:ENSMUSG00000026824 AllianceGenome:MGI:104742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GIRK1; Kcnf3; Kcnj1; GIRK-1; Kir3.1
    Summary
    Contributes to G-protein activated inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Is active in parallel fiber to Purkinje cell synapse and presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; male reproductive gland or organ; and thymus. Orthologous to human KCNJ3 (potassium inwardly rectifying channel subfamily J member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 9.5), heart adult (RPKM 8.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kcnj3 in Genome Data Viewer
    Location:
    2 C1.1; 2 31.66 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (55301814..55488157)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (55411798..55598145)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 13 Neighboring gene predicted gene, 25489 Neighboring gene STARR-seq mESC enhancer starr_04517 Neighboring gene STARR-seq mESC enhancer starr_04518 Neighboring gene STARR-positive B cell enhancer mm9_chr2:55104656-55104956 Neighboring gene cathepsin B pseudogene Neighboring gene eukaryotic translation initiation factor 4, gamma 1 pseudogene Neighboring gene oral-facial-digital syndrome 1 gene homolog pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enhanced GABAergic synaptic transmission at VLPAG neurons and potent modulation by oxycodone in a bone cancer pain model. Takasu K, et al. Br J Pharmacol, 2015 Apr. PMID 25521524, Free PMC Article
    2. Evidence for the direct interaction of spermine with the inwardly rectifying potassium channel. Osawa M, et al. J Biol Chem, 2009 Sep 18. PMID 19620244, Free PMC Article
    3. Physical determinants of strong voltage sensitivity of K(+) channel block. Xu Y, et al. Nat Struct Mol Biol, 2009 Dec. PMID 19915587, Free PMC Article
    4. Agonist-induced localization of Gq-coupled receptors and G protein-gated inwardly rectifying K+ (GIRK) channels to caveolae determines receptor specificity of phosphatidylinositol 4,5-bisphosphate signaling. Cui S, et al. J Biol Chem, 2010 Dec 31. PMID 21041306, Free PMC Article
    5. NMR analyses of the Gbetagamma binding and conformational rearrangements of the cytoplasmic pore of G protein-activated inwardly rectifying potassium channel 1 (GIRK1). Yokogawa M, et al. J Biol Chem, 2011 Jan 21. PMID 21075842, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice.
      Title: G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice.
    2. Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice.
      Title: Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice.
    3. GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation.
      Title: GIRK1-Mediated Inwardly Rectifying Potassium Current Is a Candidate Mechanism Behind Purkinje Cell Excitability, Plasticity, and Neuromodulation.
    4. Genetic Loss of IK1 Causes Adrenergic-Induced Phase 3 Early Afterdepolariz ations and Polymorphic and Bidirectional Ventricular Tachycardia.
      Title: Genetic Loss of I(K1) Causes Adrenergic-Induced Phase 3 Early Afterdepolariz ations and Polymorphic and Bidirectional Ventricular Tachycardia.
    5. Ethanol activates GIRK1 by shifting the conformational equilibrium processes, which are responsible for the gating of GIRK, to stabilize an open conformation of the cytoplasmic ion gate.
      Title: Structural basis for the ethanol action on G-protein-activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy.
    6. histone H4 hyperacetylation induced by Class I HDACs inhibitors promoted the expression profiles of potassium channels (Kcnj2, Kcnj3, Kcnj5, Kcnj11, and Kcnh2)
      Title: Regulation of Histone Acetylation on Expression Profiles of Potassium Channels During Cardiomyocyte Differentiation From Mouse Embryonic Stem Cells.
    7. Kir 3.1 channels are important for supraspinal antinociception and presynaptic GABA release inhibition by oxycodone in the femur bone cancer model
      Title: Enhanced GABAergic synaptic transmission at VLPAG neurons and potent modulation by oxycodone in a bone cancer pain model.
    8. GABA neurons in the ventral tegmental area express GIRK1 (and GIRK2) subunits.
      Title: GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner.
    9. K(IR)3.1 channels play a primary role in the antinociceptive effects of oxycodone, but not those of morphine, at supraspinal sites and suggest that supraspinal K(IR)3.1 channels are responsible for the unique analgesic profile of oxycodone.
      Title: G protein-gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites.
    10. siRNA knock-down of NgR1 resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1.
      Title: Post-transcriptional regulation of GABAB receptor and GIRK1 channels by Nogo receptor 1.
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124233, MGC124234

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to G-protein activated inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G-protein activated inward rectifier potassium channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to inward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of I(KACh) inward rectifier potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in T-tubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G protein-activated inward rectifier potassium channel 1
    Names
    G protein-gated K+ channel subunit 1 GIRK1
    inward rectifier K(+) channel Kir3.1
    potassium channel, inwardly rectifying subfamily J member 3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304810.1 → NP_001291739.1  G protein-activated inward rectifier potassium channel 1 isoform 2

      See identical proteins and their annotated locations for NP_001291739.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL929253, AW488293, BC068167
      Consensus CDS
      CCDS84524.1
      UniProtKB/TrEMBL
      B1AYE4, Q8VHS4
      Related
      ENSMUSP00000108251.2, ENSMUST00000112632.2
      Conserved Domains (1) summary
      cl21560
      Location:47 → 234
      Ion_trans_2; Ion channel

    2. NM_001355118.1 → NP_001342047.1  G protein-activated inward rectifier potassium channel 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AL845483, AL929253
      Consensus CDS
      CCDS16042.1
      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    3. NM_008426.2 → NP_032452.1  G protein-activated inward rectifier potassium channel 1 isoform 1

      See identical proteins and their annotated locations for NP_032452.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AL929253, AW488293, BC068167
      Consensus CDS
      CCDS16042.1
      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Related
      ENSMUSP00000063329.4, ENSMUST00000067101.10
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      55301814..55488157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247723.2 → XP_030103583.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    2. XM_036158746.1 → XP_036014639.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    3. XM_030247737.2 → XP_030103597.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    4. XM_030247725.2 → XP_030103585.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    5. XM_030247736.2 → XP_030103596.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    6. XM_030247738.2 → XP_030103598.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    7. XM_030247730.2 → XP_030103590.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    8. XM_030247739.2 → XP_030103599.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    9. XM_030247729.2 → XP_030103589.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    10. XM_030247740.2 → XP_030103600.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    11. XM_036158749.1 → XP_036014642.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    12. XM_030247752.2 → XP_030103612.1  G protein-activated inward rectifier potassium channel 1 isoform X3

      Conserved Domains (1) summary
      pfam17655
      Location:2 → 132
      IRK_C; Inward rectifier potassium channel C-terminal domain

    13. XM_030247722.2 → XP_030103582.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    14. XM_030247751.2 → XP_030103611.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    15. XM_030247749.2 → XP_030103609.1  G protein-activated inward rectifier potassium channel 1 isoform X1

      UniProtKB/Swiss-Prot
      P35562, P63250
      UniProtKB/TrEMBL
      Q3ZAT1
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 364
      IRK_C; Inward rectifier potassium channel C-terminal domain

    16. XM_006497731.5 → XP_006497794.1  G protein-activated inward rectifier potassium channel 1 isoform X2

      UniProtKB/TrEMBL
      Q8VHS4
      Conserved Domains (2) summary
      pfam01007
      Location:47 → 187
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:194 → 240
      IRK_C; Inward rectifier potassium channel C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63250.1 GenPept UniProtKB/Swiss-Prot:P63250

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