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    Gm614 predicted gene 614 [ Mus musculus (house mouse) ]

    Gene ID: 245536, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Gm614provided by MGI
    Official Full Name
    predicted gene 614provided by MGI
    Primary source
    MGI:MGI:2685460
    See related
    Ensembl:ENSMUSG00000090141 AllianceGenome:MGI:2685460
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within transcription by RNA polymerase II. Orthologous to human CXorf65 (chromosome X open reading frame 65). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 20.4) and thymus adult (RPKM 1.0) See more
    Orthologs
    human all
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    Genomic context

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    See Gm614 in Genome Data Viewer
    Location:
    X D; X 43.9 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100304979..100307598, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101261373..101263992, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47642 Neighboring gene predicted gene, 22472 Neighboring gene forkhead box O4 Neighboring gene STARR-seq mESC enhancer starr_47643 Neighboring gene interleukin 2 receptor, gamma chain Neighboring gene mediator complex subunit 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gm614 Protects Germinal Center B Cells From Death by Suppressing Caspase-1 Transcription in Lupus-Prone Mice. He Y, et al. Front Immunol, 2020. PMID 33193409, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gm614 Protects Germinal Center B Cells From Death by Suppressing Caspase-1 Transcription in Lupus-Prone Mice.
      Title: Gm614 Protects Germinal Center B Cells From Death by Suppressing Caspase-1 Transcription in Lupus-Prone Mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		  
    acts_upstream_of_or_within transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein CXorf65 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033362.4 → NP_001028534.1  uncharacterized protein CXorf65 homolog isoform 1

      See identical proteins and their annotated locations for NP_001028534.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL671926, AL683892
      Consensus CDS
      CCDS30311.1
      UniProtKB/Swiss-Prot
      Q3V2K1
      Related
      ENSMUSP00000098910.3, ENSMUST00000101358.3
      Conserved Domains (1) summary
      pfam15874
      Location:2 → 101
      Il2rg; Putative Interleukin 2 receptor, gamma chain

    2. NM_001317221.2 → NP_001304150.1  uncharacterized protein CXorf65 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL671926, AL683892
      Related
      ENSMUST00000125656.2
      Conserved Domains (1) summary
      pfam15874
      Location:1 → 70
      Il2rg; Putative Interleukin 2 receptor, gamma chain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      100304979..100307598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V2K1.1 GenPept UniProtKB/Swiss-Prot:Q3V2K1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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