Mki67 antigen identified by monoclonal antibody Ki 67 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mki67provided by MGI
Official Full Name: antigen identified by monoclonal antibody Ki 67provided by MGI
Primary source: MGI:MGI:106035
See related: Ensembl:ENSMUSG00000031004 AllianceGenome:MGI:106035
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ki67; Ki-67; D630048A14Rik
Summary: Predicted to enable ATP binding activity and DNA binding activity. Involved in regulation of chromatin organization. Acts upstream of or within several processes, including cholangiocyte proliferation; hepatocyte proliferation; and stem cell proliferation. Located in chromosome; cytoplasm; and nucleolus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; colorectal cancer; endocrine gland cancer (multiple); graft-versus-host disease; and human immunodeficiency virus infectious disease. Orthologous to human MKI67 (marker of proliferation Ki-67). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E14 (RPKM 21.8), liver E14.5 (RPKM 14.9) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 81.32 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (135291513..135318286, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (135689784..135716450, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement.
Title: Ki67 deficiency impedes chromatin accessibility and BCR gene rearrangement.
Immunohistochemical expression of Ki-67 and Glypican-3 to distinguish aggressive from nonaggressive benign odontogenic tumors.
Title: Immunohistochemical expression of Ki-67 and Glypican-3 to distinguish aggressive from nonaggressive benign odontogenic tumors.
Expression of Ki67 as detected by MIB-1 and its association with histopathological high-risk factors among patients with retinoblastoma tumour: a cross-sectional study.
Title: Expression of Ki67 as detected by MIB-1 and its association with histopathological high-risk factors among patients with retinoblastoma tumour: a cross-sectional study.
Changes in Ki-67 in Residual Tumor and Outcome of Primary Inflammatory Breast Cancer Treated With Trimodality Therapy.
Title: Changes in Ki-67 in Residual Tumor and Outcome of Primary Inflammatory Breast Cancer Treated With Trimodality Therapy.
Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis.
Title: Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis.
Photobiomodulation invigorating collagen deposition, proliferating cell nuclear antigen and Ki67 expression during dermal wound repair in mice.
Title: Photobiomodulation invigorating collagen deposition, proliferating cell nuclear antigen and Ki67 expression during dermal wound repair in mice.
Deletion of NKX3.1 via CRISPR/Cas9 Induces Prostatic Intraepithelial Neoplasia in C57BL/6 Mice.
Title: Deletion of NKX3.1 via CRISPR/Cas9 Induces Prostatic Intraepithelial Neoplasia in C57BL/6 Mice.
Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis.
Title: Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis.
Somatostatin Analogs for Pancreatic Neuroendocrine Tumors: Any Benefit When Ki-67 Is >/=10%?
Title: Somatostatin Analogs for Pancreatic Neuroendocrine Tumors: Any Benefit When Ki-67 Is ≥10%?
S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3.
Title: S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC290270P1 (e-PCR)
- UniSTS:272416

NoName (e-PCR)
- UniSTS:548216

X82786 (e-PCR)
- UniSTS:125869

Mki67 (e-PCR), detects polymorphism
- UniSTS:507068

PMC155645P3 (e-PCR)
- UniSTS:271345

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular condensate scaffold activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cholangiocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hepatocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic nuclear division	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with condensed chromosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: proliferation marker protein Ki-67

Names: antigen KI-67 homolog; antigen Ki67 homolog; antigen identified by monoclonal antibody Ki-67 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081117.2 → NP_001074586.2 proliferation marker protein Ki-67

Status: VALIDATED

Source sequence(s)

AC123047, AK052772, AK143677, BC053453

Consensus CDS

CCDS52421.1

UniProtKB/Swiss-Prot

E9PVX6, Q61769, Q7TSF6

Related

ENSMUSP00000033310.8, ENSMUST00000033310.9

Conserved Domains (4) summary

COG1716
Location:11 → 92

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:7 → 101

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam08065
Location:1109 → 1216

K167R; K167R (NUC007) repeat

pfam15276
Location:463 → 529

PP1_bind; Protein phosphatase 1 binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

135291513..135318286 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507413.5 → XP_006507476.1 proliferation marker protein Ki-67 isoform X2

Conserved Domains (3) summary

cd00060
Location:7 → 101

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

pfam08065
Location:1854 → 1964

K167R; K167R (NUC007) repeat

pfam15276
Location:143 → 184

PP1_bind; Protein phosphatase 1 binding
XM_036152742.1 → XP_036008635.1 proliferation marker protein Ki-67 isoform X1

Conserved Domains (2) summary

pfam08065
Location:2030 → 2140

K167R; K167R (NUC007) repeat

pfam15276
Location:318 → 360

PP1_bind; Protein phosphatase 1 binding