Rnf167 ring finger protein 167 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf167provided by MGI
Official Full Name: ring finger protein 167provided by MGI
Primary source: MGI:MGI:1917760
See related: Ensembl:ENSMUSG00000040746 AllianceGenome:MGI:1917760
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 0610010G05Rik; 5730408C10Rik
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to leucine starvation; protein polyubiquitination; and regulation of TORC1 signaling. Predicted to be located in endosome. Predicted to be active in cytosol and endolysosome membrane. Is expressed in several structures, including central nervous system; genitourinary system; liver; and neural retina. Orthologous to human RNF167 (ring finger protein 167). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 74.2), spleen adult (RPKM 51.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 43.21 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (70538056..70542247)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (70647230..70651421)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF167 is a selective regulator of AMPAR-mediated neurotransmission.
Title: Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

General gene information

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Markers

AV328608 (e-PCR)
- UniSTS:180240

RH136477 (e-PCR)
- UniSTS:210462

BE136355 (e-PCR)
- UniSTS:208698

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to leucine starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leucine starvation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in organelle localization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in protein K29-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K29-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endolysosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in endolysosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF167

Names: RING-type E3 ubiquitin transferase RNF167; novel PA domain and C3HC4 type zinc finger (RING finger) containing protein

NP_001303657.1

EC 2.3.2.27

NP_001350063.1

EC 2.3.2.27

NP_081721.1

EC 2.3.2.27

XP_006534256.1

EC 2.3.2.27

XP_006534258.1

EC 2.3.2.27

XP_036012878.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001316728.2 → NP_001303657.1 E3 ubiquitin-protein ligase RNF167 isoform 2

Status: VALIDATED

Source sequence(s)

AI840160, AK017523, AL596117

Conserved Domains (3) summary

cd00162
Location:109 → 150

RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]

cl28883
Location:1 → 49

PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

cl17238
Location:107 → 152

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001363134.1 → NP_001350063.1 E3 ubiquitin-protein ligase RNF167 isoform 2

Status: VALIDATED

Source sequence(s)

AI840160, AL596117

Conserved Domains (3) summary

cd00162
Location:109 → 150

RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]

cl28883
Location:1 → 49

PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

cl17238
Location:107 → 152

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_027445.3 → NP_081721.1 E3 ubiquitin-protein ligase RNF167 isoform 1 precursor

See identical proteins and their annotated locations for NP_081721.1

Status: VALIDATED

Source sequence(s)

AI840160, AK017523, AL596117, DV655579, DV662846

Consensus CDS

CCDS24959.1

UniProtKB/Swiss-Prot

Q3U4S5, Q91XF4

Related

ENSMUSP00000036472.8, ENSMUST00000037534.8

Conserved Domains (2) summary

cd02123
Location:20 → 170

PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...

pfam13639
Location:228 → 272

zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

70538056..70542247

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156985.1 → XP_036012878.1 E3 ubiquitin-protein ligase RNF167 isoform X2

Conserved Domains (3) summary

cd00162
Location:109 → 150

RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]

cl28883
Location:1 → 49

PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

cl17238
Location:107 → 152

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_006534193.5 → XP_006534256.1 E3 ubiquitin-protein ligase RNF167 isoform X1

See identical proteins and their annotated locations for XP_006534256.1

Conserved Domains (2) summary

cd02123
Location:1 → 135

PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...

cd16797
Location:193 → 238

RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
XM_006534195.3 → XP_006534258.1 E3 ubiquitin-protein ligase RNF167 isoform X2

See identical proteins and their annotated locations for XP_006534258.1

Conserved Domains (3) summary

cd00162
Location:109 → 150

RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]

cl28883
Location:1 → 49

PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

cl17238
Location:107 → 152

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain