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    Tpbg trophoblast glycoprotein [ Mus musculus (house mouse) ]

    Gene ID: 21983, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tpbgprovided by MGI
    Official Full Name
    trophoblast glycoproteinprovided by MGI
    Primary source
    MGI:MGI:1341264
    See related
    Ensembl:ENSMUSG00000035274 AllianceGenome:MGI:1341264
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5T4; WAIF1
    Summary
    Acts upstream of or within several processes, including dendrite arborization; olfactory learning; and positive regulation of intracellular signal transduction. Located in several cellular components, including axon terminus; dendrite; and endoplasmic reticulum. Is expressed in several structures, including brain; epithelium; extraembryonic component; skin; and urinary system. Orthologous to human TPBG (trophoblast glycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 8.0), limb E14.5 (RPKM 6.2) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tpbg in Genome Data Viewer
    Location:
    9 E3.1; 9 46.4 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (85724433..85729110)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (85842380..85847057)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24823 Neighboring gene RIKEN cDNA 9330154J02 gene Neighboring gene quinolinate phosphoribosyltransferase pseudogene Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_24825 Neighboring gene STARR-seq mESC enhancer starr_24827 Neighboring gene STARR-seq mESC enhancer starr_24828 Neighboring gene STARR-seq mESC enhancer starr_24829 Neighboring gene VISTA enhancer mm1553 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24831 Neighboring gene STARR-seq mESC enhancer starr_24832 Neighboring gene sorting nexin 4 pseudogene Neighboring gene ubiquitin protein ligase E3D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Trophoblast glycoprotein is a new candidate gene for Parkinson's disease. Park S, et al. NPJ Parkinsons Dis, 2021 Dec 7. PMID 34876581, Free PMC Article
    2. Expression of Oncofetal Antigen 5T4 in Murine Taste Papillae. Takahashi Y, et al. Front Cell Neurosci, 2019. PMID 31417363, Free PMC Article
    3. The 5T4 oncofoetal antigen is an early differentiation marker of mouse ES cells and its absence is a useful means to assess pluripotency. Ward CM, et al. J Cell Sci, 2003 Nov 15. PMID 14576347
    4. A leucine-rich repeat membrane protein, 5T4, is expressed by a subtype of granule cells with dendritic arbors in specific strata of the mouse olfactory bulb. Imamura F, et al. J Comp Neurol, 2006 Apr 20. PMID 16506198
    5. Trophoblast glycoprotein is required for efficient synaptic vesicle exocytosis from retinal rod bipolar cells. Wakeham CM, et al. Front Cell Neurosci, 2023. PMID 38099150, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the binding of osteoclast-derived CTHRC1 to WAIF1 in stromal cells activates PKCdelta-ERK osteoblastogenic signaling.
      Title: WAIF1 Is a Cell-Surface CTHRC1 Binding Protein Coupling Bone Resorption and Formation.
    2. The surface expression of 5T4 marks the use of the CXCR4 rather than the CXCR7 receptor, with distinct consequences for CXCL12 exposure.
      Title: CXCL12 receptor preference, signal transduction, biological response and the expression of 5T4 oncofoetal glycoprotein.
    3. 5T4 overexpression in newborn olfactory bulb interneurons facilitates their dendritic arborization even under a sensory input-deprived condition.
      Title: 5T4 glycoprotein regulates the sensory input-dependent development of a specific subtype of newborn interneurons in the mouse olfactory bulb.
    4. molecular interaction of 5T4 and CXCR4 occurring at the cell surface which directly facilitates the biological response to CXCL12
      Title: CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells.
    5. Spry4 and Tpbg/5T4 were detected in Kit-immunoreactive cells only in Kit(K641E), but not in Kit(WT/WT) animals.
      Title: Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours.
    6. E-cadherin protein stabilizes cortical actin cytoskeletal arrangement in embryonic stem cells, and this can prevent cell surface localization of the promigratory 5T4 antigen.
      Title: E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells.
    7. Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen
      Title: Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen.
    8. 5T4 glycoprotein expression is associated with early differentiative events of embryonic stem cells
      Title: The 5T4 oncofoetal antigen is an early differentiation marker of mouse ES cells and its absence is a useful means to assess pluripotency.
    9. Because 5T4 is known to interact with actin cytoskeleton, these observations suggest that 5T4 is involved in the formation or maintenance of strata-specific dendritic ramification or synaptic connection of subsets of local interneurons.
      Title: A leucine-rich repeat membrane protein, 5T4, is expressed by a subtype of granule cells with dendritic arbors in specific strata of the mouse olfactory bulb.
    10. A limited expression profile of 5T4 may contribute to the migration of actively cycling, undifferentiated epithelial progenitor cells during embryogenesis
      Title: Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dendrite arborization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mesenchymal cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within synaptic transmission, GABAergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trophoblast glycoprotein
    Names
    5T4 oncofetal antigen
    5T4 oncofetal trophoblast glycoprotein
    5T4 oncotrophoblast glycoprotein
    wnt-activated inhibitory factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164792.2 → NP_001158264.1  trophoblast glycoprotein precursor

      See identical proteins and their annotated locations for NP_001158264.1

      Status: VALIDATED

      Source sequence(s)
      AC158516
      Consensus CDS
      CCDS23380.1
      UniProtKB/Swiss-Prot
      Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
      Related
      ENSMUSP00000096101.4, ENSMUST00000098500.5
      Conserved Domains (4) summary
      smart00013
      Location:62 → 95
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300 → 351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:73 → 95
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:217 → 276
      LRR_8; Leucine rich repeat

    2. NM_011627.5 → NP_035757.2  trophoblast glycoprotein precursor

      See identical proteins and their annotated locations for NP_035757.2

      Status: VALIDATED

      Source sequence(s)
      AC158516
      Consensus CDS
      CCDS23380.1
      UniProtKB/Swiss-Prot
      Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
      Related
      ENSMUSP00000006559.8, ENSMUST00000006559.14
      Conserved Domains (4) summary
      smart00013
      Location:62 → 95
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300 → 351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:73 → 95
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:217 → 276
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      85724433..85729110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313282.3 → XP_017168771.1  trophoblast glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
      Conserved Domains (4) summary
      smart00013
      Location:62 → 95
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300 → 351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:73 → 95
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:217 → 276
      LRR_8; Leucine rich repeat

    2. XM_017313281.2 → XP_017168770.1  trophoblast glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
      Conserved Domains (4) summary
      smart00013
      Location:62 → 95
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300 → 351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:73 → 95
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:217 → 276
      LRR_8; Leucine rich repeat

    3. XM_017313280.2 → XP_017168769.1  trophoblast glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
      Conserved Domains (4) summary
      smart00013
      Location:62 → 95
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300 → 351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:73 → 95
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:217 → 276
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0L0.3 GenPept UniProtKB/Swiss-Prot:Q9Z0L0

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