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    uncharacterized protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856369, updated on 9-Dec-2024

    Summary

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    Official Full Name
    uncharacterized protein
    Primary source
    SGD:S000001009
    Locus tag
    YHL017W
    See related
    AllianceGenome:SGD:S000001009; FungiDB:YHL017W; VEuPathDB:YHL017W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in retrograde transport, endosome to Golgi. Located in clathrin-coated vesicle. Orthologous to human TMEM87A (transmembrane protein 87A) and TMEM87B (transmembrane protein 87B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (70276..71874)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Apm2p Neighboring gene 4a-hydroxytetrahydrobiopterin dehydratase Neighboring gene Dur3p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII. Johnston M, et al. Science, 1994 Sep 30. PMID 8091229
    2. Association of yeast Upf1p with direct substrates of the NMD pathway. Johansson MJ, et al. Proc Natl Acad Sci U S A, 2007 Dec 26. PMID 18087042, Free PMC Article
    3. Large-scale identification of yeast integral membrane protein interactions. Miller JP, et al. Proc Natl Acad Sci U S A, 2005 Aug 23. PMID 16093310, Free PMC Article
    4. The yeast SR-like protein Npl3 links chromatin modification to mRNA processing. Moehle EA, et al. PLoS Genet, 2012. PMID 23209445, Free PMC Article
    5. Interrogation of γ-tubulin alleles using high-resolution fitness measurements reveals a distinct cytoplasmic function in spindle alignment. Shulist K, et al. Sci Rep, 2017 Sep 12. PMID 28900268, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle HDA PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    NP_011846.1
    • hypothetical protein; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      70276..71874
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179097.1 → NP_011846.1  TPA: uncharacterized protein YHL017W [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011846.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKR6, P38745
      UniProtKB/TrEMBL
      B5VJR3, C7GIR9, G2WF49, N1P1E0
      Conserved Domains (1) summary
      pfam06814
      Location:152 → 444
      Lung_7-TM_R; Lung seven transmembrane receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38745.1

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