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    SAP1 putative AAA family ATPase SAP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856771, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SAP1
    Official Full Name
    putative AAA family ATPase SAP1
    Primary source
    SGD:S000000849
    Locus tag
    YER047C
    See related
    AllianceGenome:SGD:S000000849; FungiDB:YER047C; VEuPathDB:YER047C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ATP hydrolysis activity. Located in cytoplasm. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4 and nicotine dependence. Orthologous to human FIGNL1 (fidgetin like 1); FIGN (fidgetin, microtubule severing factor); and SPAST (spastin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SAP1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (243810..246503, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Aca1p Neighboring gene Spo73p Neighboring gene Caj1p Neighboring gene tRNA-Gln

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Association of yeast SAP1, a novel member of the 'AAA' ATPase family of proteins, with the chromatin protein SIN1. Liberzon A, et al. FEBS Lett, 1996 Jun 10. PMID 8654588
    2. Psr1 phosphatase regulates pre-mRNA splicing through spliceosomal B complex factor Snu66. Varikkapulakkal A, et al. FEBS J, 2024 Dec. PMID 39484844
    3. Elg1, the major subunit of an alternative RFC complex, interacts with SUMO-processing proteins. Parnas O, et al. Cell Cycle, 2011 Sep 1. PMID 21869594
    4. Sumoylation of the budding yeast kinetochore protein Ndc10 is required for Ndc10 spindle localization and regulation of anaphase spindle elongation. Montpetit B, et al. J Cell Biol, 2006 Aug 28. PMID 16923829, Free PMC Article
    5. Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Chiolo I, et al. Mol Cell Biol, 2005 Jul. PMID 15964827, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    putative AAA family ATPase SAP1
    NP_010966.1
    • Putative ATPase of the AAA family; interacts with the Sin1p transcriptional repressor in the two-hybrid system

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      243810..246503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178938.1 → NP_010966.1  TPA: putative AAA family ATPase SAP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010966.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLU8, P39955
      UniProtKB/TrEMBL
      G2WCT1
      Conserved Domains (2) summary
      COG0464
      Location:557 → 890
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam05109
      Location:353 → 543
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39955.1

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