TFB5 TFIIH complex subunit TFB5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TFB5
Official Full Name: TFIIH complex subunit TFB5
Primary source: SGD:S000007603
Locus tag: YDR079C-A
See related: AllianceGenome:SGD:S000007603; FungiDB:YDR079C-A; VEuPathDB:YDR079C-A
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to contribute to RNA polymerase II complex binding activity. Involved in nucleotide-excision repair and transcription initiation at RNA polymerase II promoter. Located in cytosol and nucleus. Part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. Human ortholog(s) of this gene implicated in photosensitive trichothiodystrophy 3. Orthologous to human GTF2H5 (general transcription factor IIH subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TFB5 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (603593..603811, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparison of the two structures revealed that the N-terminal region of Tfb2C and (to a lesser extent) the C-terminal region of Tfb5 contributed to the crystal packing.
Title: Structure determination of the minimal complex between Tfb5 and Tfb2, two subunits of the yeast transcription/DNA-repair factor TFIIH: a retrospective study.
Tfb5 is partially dispensable for Rad26 mediated transcription coupled nucleotide excision repair , especially in GG-NER deficient cells
Title: Tfb5 is partially dispensable for Rad26 mediated transcription coupled nucleotide excision repair in yeast.
TFB5 may functions as an architectural stabilizer to maintain the proper architecture of the core transcription factor TFIIH complex.
Title: Tfb5 interacts with Tfb2 and facilitates nucleotide excision repair in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to RNA polymerase II complex binding	IC Inferred by Curator more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-excision repair, preincision complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIH core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIH core complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIH core complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription factor TFIIH holo complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIH holo complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: TFIIH complex subunit TFB5

NP_076886.3

Component of RNA polymerase II general transcription factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; relocalizes to the cytosol in response to hypoxia; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

603593..603811 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184469.3 → NP_076886.3 TPA: TFIIH complex subunit TFB5 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_076886.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VS66, Q3E7C1

UniProtKB/TrEMBL

A6ZY45, B3LGJ0, C7GVQ7, C8Z4Z7, G2WAI4, N1P691

Conserved Domains (1) summary

pfam06331
Location:1 → 65

Tfb5; Transcription factor TFIIH complex subunit Tfb5