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    AGE1 GTPase-activating protein AGE1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AGE1
    Official Full Name
    GTPase-activating protein AGE1
    Primary source
    SGD:S000002932
    Locus tag
    YDR524C
    See related
    AllianceGenome:SGD:S000002932; FungiDB:YDR524C; VEuPathDB:YDR524C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SAT1
    Summary
    Enables GTPase activator activity and phospholipid binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intra-Golgi vesicle-mediated transport. Located in endosome and trans-Golgi network. Orthologous to several human genes including ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1); ASAP2 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 2); and ASAP3 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AGE1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1487542..1488990, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Sps2p Neighboring gene putative serine/threonine protein kinase SPS1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A family of Arf effectors defined as suppressors of the loss of Arf function in the yeast Saccharomyces cerevisiae. Zhang CJ, et al. J Biol Chem, 1998 Jul 31. PMID 9677411
    2. Four ARF GAPs in Saccharomyces cerevisiae have both overlapping and distinct functions. Zhang CJ, et al. Yeast, 2003 Mar. PMID 12627398
    3. The yeast Arf GTPase-activating protein Age1 is regulated by phospholipase D for post-Golgi vesicular transport. Benjamin JJ, et al. J Biol Chem, 2011 Feb 18. PMID 21135091, Free PMC Article
    4. Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi. Wong TA, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16126894, Free PMC Article
    5. Requirement of a specific group of sphingolipid-metabolizing enzyme for growth of yeast Saccharomyces cerevisiae under impaired metabolism of glycerophospholipids. Tani M, et al. Mol Microbiol, 2010 Oct. PMID 20979339

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. by direct assessment of Age1 ArfGAP activity that Age1 is regulated by lipid composition and can provide ArfGAP function for post-Golgi transport
      Title: The yeast Arf GTPase-activating protein Age1 is regulated by phospholipase D for post-Golgi vesicular transport.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GTPase-activating protein AGE1
    NP_010812.3
    • ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1487542..1488990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180832.3 → NP_010812.3  TPA: GTPase-activating protein AGE1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010812.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTE4, Q04412
      UniProtKB/TrEMBL
      C7GKV5, N1P938
      Conserved Domains (1) summary
      COG5347
      Location:164 → 480
      COG5347; GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04412.1

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