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    SAS4 Sas4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851762, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SAS4
    Official Full Name
    Sas4p
    Primary source
    SGD:S000002589
    Locus tag
    YDR181C
    See related
    AllianceGenome:SGD:S000002589; FungiDB:YDR181C; VEuPathDB:YDR181C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables histone acetyltransferase activity. Involved in subtelomeric heterochromatin formation. Located in chromatin. Part of SAS acetyltransferase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SAS4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (825910..827355, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Nvj3p Neighboring gene cohesin-loading factor complex subunit SCC2 Neighboring gene putative lipid phosphatase CDC1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of SAS4 and SAS5, two genes that regulate silencing in Saccharomyces cerevisiae. Xu EY, et al. Genetics, 1999 Sep. PMID 10471696, Free PMC Article
    2. Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex. Sutton A, et al. J Biol Chem, 2003 May 9. PMID 12626510
    3. Proliferating cell nuclear antigen (PCNA) is required for cell cycle-regulated silent chromatin on replicated and nonreplicated genes. Miller A, et al. J Biol Chem, 2010 Nov 5. PMID 20813847, Free PMC Article
    4. Positive roles of SAS2 in DNA replication and transcriptional silencing in yeast. Zou Y, et al. Nucleic Acids Res, 2008 Sep. PMID 18682530, Free PMC Article
    5. SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae. Xu EY, et al. Genetics, 1999 Sep. PMID 10471697, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in subtelomeric heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAS acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAS acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAS acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sas4p
    NP_010467.1
    • Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      825910..827355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180489.1 → NP_010467.1  TPA: Sas4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010467.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSG4, Q04003
      UniProtKB/TrEMBL
      B3LGA1, B5VG75, C8Z595
      Conserved Domains (1) summary
      pfam15460
      Location:124 → 222
      SAS4; Something about silencing, SAS, complex subunit 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04003.1

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