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    SAC3 Sac3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SAC3
    Official Full Name
    Sac3p
    Primary source
    SGD:S000002566
    Locus tag
    YDR159W
    See related
    AllianceGenome:SGD:S000002566; FungiDB:YDR159W; VEuPathDB:YDR159W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LEP1
    Summary
    Involved in several processes, including mRNA metabolic process; nuclear export; and post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery. Part of nuclear pore cytoplasmic filaments and transcription export complex 2. Orthologous to several human genes including SAC3D1 (SAC3 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SAC3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (771877..775782)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase I subunit RPA14 Neighboring gene uncharacterized protein Neighboring gene aspartate-semialdehyde dehydrogenase Neighboring gene Ssy1p Neighboring gene Acl4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the Sac3 RNA-binding M-region in the Saccharomyces cerevisiae TREX-2 complex. Gordon JMB, et al. Nucleic Acids Res, 2017 May 19. PMID 28334829, Free PMC Article
    2. Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2. Dimitrova L, et al. Structure, 2015 Jul 7. PMID 26051714, Free PMC Article
    3. The SAC3 gene encodes a nuclear protein required for normal progression of mitosis. Bauer A, et al. J Cell Sci, 1996 Jun. PMID 8799844
    4. Characterization of the SAC3 gene of Saccharomyces cerevisiae. Bauer A, et al. Yeast, 1996 Aug. PMID 8873450
    5. The yeast Apq12 protein affects nucleocytoplasmic mRNA transport. Baker KE, et al. RNA, 2004 Sep. PMID 15273328, Free PMC Article

    See all (143) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the TREX-2 complex the TPR-like repeat region of the Sac3 chain extends further towards the N-terminus than had been previously thought.
      Title: The Sac3 TPR-like region in the Saccharomyces cerevisiae TREX-2 complex is more extensive but independent of the CID region.
    2. Study finds that the TREX-2 complex (1) interacts with the Mediator Med31 submodule via the Sac3 PCI domain, (2) regulates Mediator association with the Cdk8 kinase, (3) impacts on Pol II carboxyl terminus domain Ser5 phosphorylation, and (4) employs a similar, conserved Sac3 PCI domain surface to promote transcription and mRNA export.
      Title: The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression.
    3. Data show that the Sus1-binding site on Sgf11 is somewhat shorter than on Sac3 and is based on a narrower hydrophobic stripe.
      Title: Structural basis for the interaction between yeast Spt-Ada-Gcn5 acetyltransferase (SAGA) complex components Sgf11 and Sus1.
    4. Thp1-Sac3-Sus1-Cdc31, together with THO/TREX, define a specific pathway connecting transcription elongation with export via an RNA-dependent dynamic process
      Title: The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament-based process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear mRNA surveillance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription-coupled nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore cytoplasmic filaments IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription export complex 2 IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription export complex 2 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription export complex 2 IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sac3p
    NP_010443.3
    • mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      771877..775782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180466.3 → NP_010443.3  TPA: Sac3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010443.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSD9, P46674
      UniProtKB/TrEMBL
      B3LGC5, C7GX39
      Conserved Domains (1) summary
      COG5079
      Location:103 → 812
      SAC3; Nuclear protein export factor [Intracellular trafficking and secretion / Cell division and chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46674.2

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