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    YBP1 Ybp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852517, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YBP1
    Official Full Name
    Ybp1p
    Primary source
    SGD:S000000420
    Locus tag
    YBR216C
    See related
    AllianceGenome:SGD:S000000420; FungiDB:YBR216C; VEuPathDB:YBR216C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription factor binding activity and protein-disulfide reductase activity. Involved in protein oxidation and protein-containing complex assembly. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YBP1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (655576..657600, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Sds24p Neighboring gene Hpc2p Neighboring gene Atg12p Neighboring gene pyruvate carboxylase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ybp1 is required for the hydrogen peroxide-induced oxidation of the Yap1 transcription factor. Veal EA, et al. J Biol Chem, 2003 Aug 15. PMID 12743123
    2. Enhancing Saccharomyces cerevisiae reactive oxygen species and ethanol stress tolerance for high-level production of protopanoxadiol. Zhao F, et al. Bioresour Technol, 2017 Mar. PMID 28040652
    3. Differential oxidant tolerance determined by the key transcription factor Yap1 is controlled by levels of the Yap1-binding protein, Ybp1. Gulshan K, et al. J Biol Chem, 2011 Sep 30. PMID 21844193, Free PMC Article
    4. YBP1 and its homologue YBP2/YBH1 influence oxidative-stress tolerance by nonidentical mechanisms in Saccharomyces cerevisiae. Gulshan K, et al. Eukaryot Cell, 2004 Apr. PMID 15075262, Free PMC Article
    5. A scaffold protein that chaperones a cysteine-sulfenic acid in H(2)O(2) signaling. Bersweiler A, et al. Nat Chem Biol, 2017 Aug. PMID 28628095

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ybp1 is rate-limiting for Yap1 oxidative folding during H(2)O(2) stress.
      Title: Differential oxidant tolerance determined by the key transcription factor Yap1 is controlled by levels of the Yap1-binding protein, Ybp1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ybp1p
    NP_009775.3
    • Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      655576..657600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178564.3 → NP_009775.3  TPA: Ybp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009775.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQL2, P38315
      UniProtKB/TrEMBL
      A6ZLF6, G2W9L9
      Conserved Domains (1) summary
      pfam08568
      Location:1 → 669
      Kinetochor_Ybp2; Uncharacterized protein family, YAP/Alf4/glomulin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38315.1

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