U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RFS1 flavodoxin-like fold family protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852341, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RFS1
    Official Full Name
    flavodoxin-like fold family protein
    Primary source
    SGD:S000000256
    Locus tag
    YBR052C
    See related
    AllianceGenome:SGD:S000000256; FungiDB:YBR052C; VEuPathDB:YBR052C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable FMN binding activity and oxidoreductase activity. Acts upstream of or within positive regulation of ferroptosis. Located in cytoplasm and eisosome. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RFS1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (338720..339352, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene DNA-binding protein REB1 Neighboring gene protein phosphatase regulator REG2 Neighboring gene uncharacterized protein Neighboring gene Yro2p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Saccharomyces cerevisiae flavodoxin-like proteins Ycp4 and Rfs1 play a role in stress response and in the regulation of genes related to metabolism. Cardona F, et al. Arch Microbiol, 2011 Jul. PMID 21442317
    2. Ferroptosis-protective membrane domains in quiescence. Megarioti AH, et al. Cell Rep, 2023 Dec 26. PMID 38096056
    3. The plasma membrane-enriched fraction proteome response during adaptation to hydrogen peroxide in Saccharomyces cerevisiae. Pedroso N, et al. Free Radic Res, 2012 Oct. PMID 22712517
    4. Plasma membrane microdomains regulate turnover of transport proteins in yeast. Grossmann G, et al. J Cell Biol, 2008 Dec 15. PMID 19064668, Free PMC Article
    5. Different mating-type-regulated genes affect the DNA repair defects of Saccharomyces RAD51, RAD52 and RAD55 mutants. Valencia-Burton M, et al. Genetics, 2006 Sep. PMID 16782999, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YCP4 and RFS1 have a clear role in the regulation of metabolism at the late stages of growth.
      Title: The Saccharomyces cerevisiae flavodoxin-like proteins Ycp4 and Rfs1 play a role in stress response and in the regulation of genes related to metabolism.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of ferroptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in eisosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    flavodoxin-like fold family protein
    NP_009608.1
    • hypothetical protein; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      338720..339352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178400.1 → NP_009608.1  TPA: flavodoxin-like fold family protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009608.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ51, P38234
      UniProtKB/TrEMBL
      A6ZKZ5, B3LN97, C7GST8, D3UEE7, G2W957, N1P810
      Conserved Domains (1) summary
      cl00438
      Location:1 → 201
      FMN_red; NADPH-dependent FMN reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38234.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools