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    OPY2 Opy2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856191, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OPY2
    Official Full Name
    Opy2p
    Primary source
    SGD:S000006279
    Locus tag
    YPR075C
    See related
    AllianceGenome:SGD:S000006279; FungiDB:YPR075C; VEuPathDB:YPR075C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in several processes, including mitotic cell cycle G1 arrest in response to pheromone; osmosensory signaling pathway; and positive regulation of filamentous growth of a population of unicellular organisms in response to starvation. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See OPY2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (695737..696819, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tyrosine protein phosphatase LTP1 Neighboring gene transketolase TKL1 Neighboring gene uncharacterized protein Neighboring gene Mrl1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The transmembrane protein Opy2 mediates activation of the Cek1 MAP kinase in Candida albicans. Herrero de Dios C, et al. Fungal Genet Biol, 2013 Jan. PMID 23149115
    2. Binding of the Extracellular Eight-Cysteine Motif of Opy2 to the Putative Osmosensor Msb2 Is Essential for Activation of the Yeast High-Osmolarity Glycerol Pathway. Yamamoto K, et al. Mol Cell Biol, 2016 Feb 1. PMID 26598606, Free PMC Article
    3. Interaction between the transmembrane domains of Sho1 and Opy2 enhances the signaling efficiency of the Hog1 MAP kinase cascade in Saccharomyces cerevisiae. Takayama T, et al. PLoS One, 2019. PMID 30682143, Free PMC Article
    4. Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway. Ekiel I, et al. Mol Biol Cell, 2009 Dec. PMID 19846660, Free PMC Article
    5. Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway. Tatebayashi K, et al. EMBO J, 2007 Aug 8. PMID 17627274, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sho1-Opy2 interaction enhances the activation of Pbs2 by Ste11, but not Hog1 by Pbs2. Chemical crosslinking and mutational analyses revealed that the cytoplasmic ends of Sho1 TM1 and Opy2 TM also interact with each other, defining the Sho1-Opy2 binding site 2 (BS2).
      Title: Interaction between the transmembrane domains of Sho1 and Opy2 enhances the signaling efficiency of the Hog1 MAP kinase cascade in Saccharomyces cerevisiae.
    2. The extracellular cysteine-rich domain of the transmembrane-anchor protein Opy2 binds to the Hkr1-Msb2 homology domain of the putative osmosensor Msb2 and the formation of the Opy2-Msb2 complex is essential for osmotic activation of Hog1.
      Title: Binding of the Extracellular Eight-Cysteine Motif of Opy2 to the Putative Osmosensor Msb2 Is Essential for Activation of the Yeast High-Osmolarity Glycerol Pathway.
    3. Dynamic regulation of Ste50-Opy2 interaction fine-tunes the MAPK signaling network.
      Title: Dynamic control of yeast MAP kinase network by induced association and dissociation between the Ste50 scaffold and the Opy2 membrane anchor.
    4. Two peptide motifs within the intrinsically disordered cytoplasmic tail of Opy2p physically interact with the Step50p-RA domain.
      Title: Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic cell cycle G1 arrest in response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in osmosensory signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in osmosensory signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of filamentous growth of a population of unicellular organisms in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Opy2p
    NP_015400.1
    • Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      695737..696819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184172.1 → NP_015400.1  TPA: Opy2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015400.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W479, Q06810, Q6B149
      UniProtKB/TrEMBL
      B3LLC7, B5VTM2, N1NW28
      Conserved Domains (1) summary
      pfam09463
      Location:30 → 63
      Opy2; Opy2 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06810.1

    Gene LinkOut

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