ESA1 NuA4 histone acetyltransferase complex catalytic subunit ESA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ESA1
Official Full Name: NuA4 histone acetyltransferase complex catalytic subunit ESA1
Primary source: SGD:S000005770
Locus tag: YOR244W
See related: AllianceGenome:SGD:S000005770; FungiDB:YOR244W; VEuPathDB:YOR244W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: KAT5; TAS1
Summary: Enables histone H4 acetyltransferase activity; histone crotonyltransferase activity; and transcription coregulator activity. Involved in several processes, including DNA-templated transcription elongation; positive regulation of macroautophagy; and regulation of gene expression. Located in chromatin. Part of NuA4 histone acetyltransferase complex and piccolo histone acetyltransferase complex. Used to study cancer. Orthologous to human KAT5 (lysine acetyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ESA1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (792531..793868)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Uncovering the Role of the Yeast Lysine Acetyltransferase NuA4 in the Regulation of Nuclear Shape and Lipid Metabolism.
Title: Uncovering the Role of the Yeast Lysine Acetyltransferase NuA4 in the Regulation of Nuclear Shape and Lipid Metabolism.
Structure of the NuA4 histone acetyltransferase complex.
Title: Structure of the NuA4 histone acetyltransferase complex.
Structure and flexibility of the yeast NuA4 histone acetyltransferase complex.
Title: Structure and flexibility of the yeast NuA4 histone acetyltransferase complex.
A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans.
Title: A balancing act: interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans.
Structure of the NuA4 acetyltransferase complex bound to the nucleosome.
Title: Structure of the NuA4 acetyltransferase complex bound to the nucleosome.
Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization.
Title: Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization.
ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.
Title: ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.
Interaction of replication factor Sld3 and histone acetyl transferase Esa1 alleviates gene silencing and promotes the activation of late and dormant replication origins.
Title: Interaction of replication factor Sld3 and histone acetyl transferase Esa1 alleviates gene silencing and promotes the activation of late and dormant replication origins.
Dynamic regulation of Pif1 acetylation is crucial to the maintenance of genome stability.
Title: Dynamic regulation of Pif1 acetylation is crucial to the maintenance of genome stability.
Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes.
Title: Swc4 positively regulates telomere length independently of its roles in NuA4 and SWR1 complexes.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K122 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K18 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K23 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone crotonyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone crotonyltransferase activity	IEA Inferred from Electronic Annotation more info
enables peptide 2-hydroxyisobutyryltransferase activity	IEA Inferred from Electronic Annotation more info
enables peptide N-acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IGI Inferred from Genetic Interaction more info	PubMed
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA-templated transcription elongation	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA-templated transcription elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rDNA heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in rDNA heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of histone acetyltransferase complex	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of piccolo histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NuA4 histone acetyltransferase complex catalytic subunit ESA1

NP_014887.3

EC 2.3.1.48

Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases, functionally complements lethality of the esa1 null mutation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

792531..793868

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183663.3 → NP_014887.3 TPA: NuA4 histone acetyltransferase complex catalytic subunit ESA1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014887.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2U6, Q08649

UniProtKB/TrEMBL

A6ZP83, B3LJR3, C7GWE4, C8ZGZ6, G2WNB2, N1NWU8

Conserved Domains (1) summary

COG5027
Location:16 → 431

SAS2; Histone acetyltransferase (MYST family) [Chromatin structure and dynamics]