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    AFI1 Afi1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854296, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AFI1
    Official Full Name
    Afi1p
    Primary source
    SGD:S000005655
    Locus tag
    YOR129C
    See related
    AllianceGenome:SGD:S000005655; FungiDB:YOR129C; VEuPathDB:YOR129C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in actin cortical patch localization and cellular bud site selection. Located in cellular bud neck; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AFI1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (566877..569558, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein RGA1 Neighboring gene phosphoribosylaminoimidazole carboxylase ADE2 Neighboring gene Ort1p Neighboring gene tRNA-Asp

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. YOR129c, a new element interacting with Cnm67p, a component of the spindle pole body of Saccharomyces cerevisiae. Wysocka M, et al. Acta Biochim Pol, 2003. PMID 14515169
    2. Afi1p functions as an Arf3p polarization-specific docking factor for development of polarity. Tsai PC, et al. J Biol Chem, 2008 Jun 13. PMID 18397879
    3. Whi3, an S. cerevisiae RNA-binding protein, is a component of stress granules that regulates levels of its target mRNAs. Holmes KJ, et al. PLoS One, 2013. PMID 24386330, Free PMC Article
    4. The polarisome is required for segregation and retrograde transport of protein aggregates. Liu B, et al. Cell, 2010 Jan 22. PMID 20141839
    5. Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum. Colomina N, et al. J Biol Chem, 2008 Oct 17. PMID 18667435, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Afi1p functions as an Arf3p polarization-specific adapter and participates in development of polarity [Afi1p]
      Title: Afi1p functions as an Arf3p polarization-specific docking factor for development of polarity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cortical patch localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cortical patch localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin cortical patch localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular bud site selection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular bud site selection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular bud neck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Afi1p
    NP_014772.1
    • Arf3p polarization-specific docking factor; required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      566877..569558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183548.1 → NP_014772.1  TPA: Afi1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014772.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2I7, Q92274, Q99222
      UniProtKB/TrEMBL
      A6ZNX6, G2WN04, N1P362
      Conserved Domains (2) summary
      pfam07792
      Location:29 → 188
      Afi1; Docking domain of Afi1 for Arf3 in vesicle trafficking
      cl40631
      Location:348 → 469
      SPA; Stabilization of polarity axis
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99222.1

    Gene LinkOut

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