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    TMC1 Tmc1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854217, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TMC1
    Official Full Name
    Tmc1p
    Primary source
    SGD:S000005578
    Locus tag
    YOR052C
    See related
    AllianceGenome:SGD:S000005578; FungiDB:YOR052C; VEuPathDB:YOR052C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YOR29-03
    Summary
    Predicted to enable zinc ion binding activity. Involved in cellular response to arsenic-containing substance and cellular response to misfolded protein. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TMC1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (426772..427224, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene phospholipid-translocating ATPase RSB1 Neighboring gene Ett1p Neighboring gene phosphopantothenoylcysteine decarboxylase complex subunit VHS3 Neighboring gene rRNA-binding endoribonuclease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae. Schüller C, et al. Mol Biol Cell, 2004 Feb. PMID 14617816, Free PMC Article
    2. Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity. Hanna J, et al. J Biol Chem, 2014 Jan 17. PMID 24297164, Free PMC Article
    3. Unraveling networks of co-regulated genes on the sole basis of genome sequences. Brohée S, et al. Nucleic Acids Res, 2011 Aug. PMID 21572103, Free PMC Article
    4. Identification of direct and indirect targets of the Gln3 and Gat1 activators by transcriptional profiling in response to nitrogen availability in the short and long term. Scherens B, et al. FEMS Yeast Res, 2006 Aug. PMID 16879428
    5. Tmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response. Guerra-Moreno A, et al. J Biol Chem, 2016 Jul 8. PMID 27226598, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to arsenic-containing substance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to misfolded protein IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tmc1p
    NP_014695.1
    • AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      426772..427224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183471.1 → NP_014695.1  TPA: Tmc1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014695.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2B7, O00017, Q08422
      UniProtKB/TrEMBL
      A6ZNQ6, B3LJA3, C7GLH9, C8ZI13, G2WMT2, N1NWV7
      Conserved Domains (1) summary
      COG3582
      Location:1 → 149
      COG3582; Predicted nucleic acid binding protein containing the AN1-type Zn-finger [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08422.1

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