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    PEP12 SNAP receptor PEP12 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854201, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PEP12
    Official Full Name
    SNAP receptor PEP12
    Primary source
    SGD:S000005562
    Locus tag
    YOR036W
    See related
    AllianceGenome:SGD:S000005562; FungiDB:YOR036W; VEuPathDB:YOR036W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VPL6; VPS6; VPT13
    Summary
    Enables SNAP receptor activity. Involved in macroautophagy; vacuolar transport; and vacuole inheritance. Located in Golgi apparatus and endosome. Orthologous to several human genes including STX12 (syntaxin 12). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PEP12 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (400348..401214)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene She4p Neighboring gene oxidoreductase Neighboring gene Hir2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Candida albicans PEP12 is required for biofilm integrity and in vivo virulence. Palanisamy SK, et al. Eukaryot Cell, 2010 Feb. PMID 20023068, Free PMC Article
    2. Pep12p is a multifunctional yeast syntaxin that controls entry of biosynthetic, endocytic and retrograde traffic into the prevacuolar compartment. Gerrard SR, et al. Traffic, 2000 Mar. PMID 11208109
    3. Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast. Becherer KA, et al. Mol Biol Cell, 1996 Apr. PMID 8730101, Free PMC Article
    4. Acidification of the lysosome-like vacuole and the vacuolar H+-ATPase are deficient in two yeast mutants that fail to sort vacuolar proteins. Rothman JH, et al. J Cell Biol, 1989 Jul. PMID 2526133, Free PMC Article
    5. Pth1/Vam3p is the syntaxin homolog at the vacuolar membrane of Saccharomyces cerevisiae required for the delivery of vacuolar hydrolases. Srivastava A, et al. Genetics, 1998 Jan. PMID 9475723, Free PMC Article

    See all (148) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNAP receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SNAP receptor PEP12
    NP_014679.1
    • Target membrane receptor (t-SNARE); for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      400348..401214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183455.1 → NP_014679.1  TPA: SNAP receptor PEP12 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014679.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2A3, P32854
      UniProtKB/TrEMBL
      A6ZNP1, B3LJ89, B5VRT8, C7GLG5, C8ZHZ8, G2WMR8, N1NVR1
      Conserved Domains (1) summary
      COG5325
      Location:4 → 288
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32854.2

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