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    BIO5 Bio5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855793, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BIO5
    Official Full Name
    Bio5p
    Primary source
    SGD:S000005339
    Locus tag
    YNR056C
    See related
    AllianceGenome:SGD:S000005339; FungiDB:YNR056C; VEuPathDB:YNR056C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables transmembrane transporter activity. Involved in biotin biosynthetic process and vitamin transport. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BIO5 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (731618..733303, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene Hol1p Neighboring gene dethiobiotin synthase Neighboring gene adenosylmethionine-8-amino-7-oxononanoate transaminase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vhr1p, a new transcription factor from budding yeast, regulates biotin-dependent expression of VHT1 and BIO5. Weider M, et al. J Biol Chem, 2006 May 12. PMID 16533810
    2. Characterization of the biotin biosynthesis pathway in Saccharomyces cerevisiae and evidence for a cluster containing BIO5, a novel gene involved in vitamer uptake. Phalip V, et al. Gene, 1999 May 17. PMID 10333520
    3. Identification by comparative transcriptomics of core regulatory genes for higher alcohol production in a top-fermenting yeast at different temperatures in beer fermentation. Sun ZG, et al. Appl Microbiol Biotechnol, 2019 Jun. PMID 31073877
    4. Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis. Mattiazzi Ušaj M, et al. Metallomics, 2015 Sep. PMID 26067383
    5. A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Aguilar PS, et al. Nat Struct Mol Biol, 2010 Jul. PMID 20526336, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The presented data characterize Vhr1p as an essential component of the biotin-dependent signal transduction cascade in yeast.
      Title: Vhr1p, a new transcription factor from budding yeast, regulates biotin-dependent expression of VHT1 and BIO5.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables gamma-aminobutyric acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biotin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vitamin transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vitamin transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bio5p
    NP_014454.3
    • Putative transmembrane protein involved in the biotin biosynthesis; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      731618..733303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183233.3 → NP_014454.3  TPA: Bio5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014454.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1N1, P53744
      UniProtKB/TrEMBL
      A6ZSD0, B5VR81, N1NXU5
      Conserved Domains (1) summary
      TIGR00907
      Location:38 → 555
      2A0304; amino acid permease (GABA permease)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53744.1

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