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    SNF12 Snf12p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SNF12
    Official Full Name
    Snf12p
    Primary source
    SGD:S000005306
    Locus tag
    YNR023W
    See related
    AllianceGenome:SGD:S000005306; FungiDB:YNR023W; VEuPathDB:YNR023W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SWP73
    Summary
    A structural constituent of chromatin. Involved in cellular response to amino acid starvation; chromatin remodeling; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Part of SWI/SNF complex. Is active in chromatin. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 11. Orthologous to human SMARCD1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1); SMARCD2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2); and SMARCD3 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SNF12 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (670418..672118)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial 54S ribosomal protein MRPL50 Neighboring gene Mpp6p Neighboring gene Sar family guanine nucleotide exchange factor SEC12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adenovirus E1A specifically blocks SWI/SNF-dependent transcriptional activation. Miller ME, et al. Mol Cell Biol, 1996 Oct. PMID 8816487, Free PMC Article
    2. NRG1 is required for glucose repression of the SUC2 and GAL genes of Saccharomyces cerevisiae. Zhou H, et al. BMC Genet, 2001. PMID 11281938, Free PMC Article
    3. Essential role of Swp73p in the function of yeast Swi/Snf complex. Cairns BR, et al. Genes Dev, 1996 Sep 1. PMID 8804308
    4. The C-terminal domain of Sin1 interacts with the SWI-SNF complex in yeast. Pérez-Martín J, et al. Mol Cell Biol, 1998 Jul. PMID 9632800, Free PMC Article
    5. RSC, an essential, abundant chromatin-remodeling complex. Cairns BR, et al. Cell, 1996 Dec 27. PMID 8980231

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of chromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Snf12p
    NP_014420.1
    • 73 kDa subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive; SNF12 has a paralog, RSC6, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      670418..672118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183200.1 → NP_014420.1  TPA: Snf12p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1J8, P53628
      UniProtKB/TrEMBL
      A6ZS97, B3LPM0, C7GLN4, C8ZFQ0, N1NXR5
      Conserved Domains (1) summary
      COG5531
      Location:121 → 464
      Rsc6; Chromatin remodeling complex protein RSC6, contains SWIB domain [Chromatin structure and dynamics]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53628.1

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