ADE12 adenylosuccinate synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ADE12
Official Full Name: adenylosuccinate synthase
Primary source: SGD:S000005164
Locus tag: YNL220W
See related: AllianceGenome:SGD:S000005164; FungiDB:YNL220W; VEuPathDB:YNL220W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BRA9
Summary: Enables DNA replication origin binding activity and adenylosuccinate synthase activity. Involved in purine nucleotide biosynthetic process. Located in cytoplasm. Orthologous to several human genes including ADSS2 (adenylosuccinate synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ADE12 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (234413..235714)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

genes ADE12, ADE13, AAH1, and HAM1 controlling processes of purine utilization and interconversion in yeast make the greatest contribution to the system of protection against the toxic and mutagenic action of the examined analogs.
Title: [Genetic control of metabolism of mutagenic purine base analogs 6-hydroxylaminopurine and 2-amino-6-hydroxylaminopurine in yeast Saccharomyces cerevisiae].

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA replication origin binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables adenylosuccinate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylosuccinate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylosuccinate synthase activity	IEA Inferred from Electronic Annotation more info
enables adenylosuccinate synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' AMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' AMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in IMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenylosuccinate synthase

NP_014179.1

EC 6.3.4.4

Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

234413..235714

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183058.1 → NP_014179.1 TPA: adenylosuccinate synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014179.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZRM0, C7GPD7, D6W0X0, P80210

UniProtKB/TrEMBL

G2WLP3, N1NZ63

Conserved Domains (1) summary

pfam00709
Location:4 → 428

Adenylsucc_synt; Adenylosuccinate synthetase