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    NPL6 Npl6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855116, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NPL6
    Official Full Name
    Npl6p
    Primary source
    SGD:S000004697
    Locus tag
    YMR091C
    See related
    AllianceGenome:SGD:S000004697; FungiDB:YMR091C; VEuPathDB:YMR091C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RSC7
    Summary
    Predicted to enable chromatin DNA binding activity. Involved in nucleosome disassembly and transcription elongation by RNA polymerase II. Located in nucleus. Part of RSC-type complex. Human ortholog(s) of this gene implicated in renal Wilms' tumor. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NPL6 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (450058..451365, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene m-AAA protease subunit YTA12 Neighboring gene uncharacterized protein Neighboring gene Aip1p Neighboring gene snoRNA-binding rRNA-processing protein UTP15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein. Sadler I, et al. J Cell Biol, 1989 Dec. PMID 2556404, Free PMC Article
    2. Chromatin remodelers act globally, sequence positions nucleosomes locally. Partensky PD, et al. J Mol Biol, 2009 Aug 7. PMID 19450608, Free PMC Article
    3. Hsp90 and p23 Molecular Chaperones Control Chromatin Architecture by Maintaining the Functional Pool of the RSC Chromatin Remodeler. Echtenkamp FJ, et al. Mol Cell, 2016 Dec 1. PMID 27818141, Free PMC Article
    4. Dual chromatin remodeling roles for RSC during DNA double strand break induction and repair at the yeast MAT locus. Kent NA, et al. J Biol Chem, 2007 Sep 21. PMID 17652077
    5. The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion. Sing TL, et al. J Cell Biol, 2018 Jul 2. PMID 29875260, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RSC-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Npl6p
    NP_013809.1
    • Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      450058..451365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182591.1 → NP_013809.1  TPA: Npl6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013809.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZR4, P32832
      UniProtKB/TrEMBL
      A6ZME8, B5VPL7, C7GL35, C8ZEU4, G2WKD9
      Conserved Domains (1) summary
      pfam08624
      Location:121 → 253
      CRC_subunit; Chromatin remodelling complex Rsc7/Swp82 subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32832.1

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