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    PDS5 Pds5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855099, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PDS5
    Official Full Name
    Pds5p
    Primary source
    SGD:S000004681
    Locus tag
    YMR076C
    See related
    AllianceGenome:SGD:S000004681; FungiDB:YMR076C; VEuPathDB:YMR076C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables structural molecule activity. Involved in DNA metabolic process; chromatin looping; and chromosome organization. Acts upstream of or within synaptonemal complex assembly. Located in condensed nuclear chromosome and cytosol. Part of meiotic recombination initiation complex. Orthologous to human PDS5A (PDS5 cohesin associated factor A) and PDS5B (PDS5 cohesin associated factor B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PDS5 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (416196..420029, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Sdd2p Neighboring gene Rco1p Neighboring gene uncharacterized protein Neighboring gene tRNA-Val Neighboring gene ESCRT-III subunit protein VPS20

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutation of the cohesin related gene PDS5 causes cell death with predominant apoptotic features in Saccharomyces cerevisiae during early meiosis. Ren Q, et al. Mutat Res, 2005 Mar 1. PMID 15708575
    2. Pds5 is required for homologue pairing and inhibits synapsis of sister chromatids during yeast meiosis. Jin H, et al. J Cell Biol, 2009 Sep 7. PMID 19736318, Free PMC Article
    3. Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae. Tong K, et al. PLoS One, 2014. PMID 24963665, Free PMC Article
    4. Meiotic prophase roles of Pds5 in recombination and chromosome condensation in budding yeast. Joo JH, et al. J Microbiol, 2022 Feb. PMID 35102525
    5. Budding yeast PDS5 plays an important role in meiosis and is required for sister chromatid cohesion. Zhang Z, et al. Mol Microbiol, 2005 May. PMID 15819623

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. S. cerevisiae Cells Can Grow without the Pds5 Cohesin Subunit.
      Title: S. cerevisiae Cells Can Grow without the Pds5 Cohesin Subunit.
    2. Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops.
      Title: Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops.
    3. ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.
      Title: ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.
    4. PDS5A and PDS5B in Cohesin Function and Human Disease.
      Title: PDS5A and PDS5B in Cohesin Function and Human Disease.
    5. Pds5+Rec8] promotes double-strand break formation, maintains homolog bias for crossover formation and promotes S-phase progression.
      Title: Recruitment of Rec8, Pds5 and Rad61/Wapl to meiotic homolog pairing, recombination, axis formation and S-phase.
    6. the integrity of the Pds5-Scc1 interface is indispensable for the recruitment of Pds5 to cohesin, and that its abrogation results in loss of sister chromatid cohesion and cell viability.
      Title: Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function.
    7. a novel role for Pds5 in Saccharomyces cerevisiae
      Title: Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae.
    8. propose that Pds5 maintains cohesion, at least in part, by antagonizing the polySUMO-dependent degradation of cohesin
      Title: Pds5 prevents the PolySUMO-dependent separation of sister chromatids.
    9. Data indicate that cell cycle protein Pds5 promotes acetylation of cohesin subunit Smc3 by acetyltransferase Eco1 during S phase.
      Title: Pds5 promotes and protects cohesin acetylation.
    10. Scc3 and Pds5 are cohesin maintenance factors required for cohesin ring stability or for maintaining its association with DNA.
      Title: Cohesin rings devoid of Scc3 and Pds5 maintain their stable association with the DNA.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural molecule activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA double-strand break formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of meiotic recombination initiation complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pds5p
    NP_013793.1
    • Cohesion maintenance factor; involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes; performs its cohesin maintenance function in pre-anaphase cells by protecting the integrity of the cohesion complex; regulates homolog pairing and facilitates synaptonemal complex formation, axis formation, interhomolog recombination and synapsis during meiosis; relocalizes to the cytosol in response to hypoxia; scaffolding protein contains 26 HEAT repeats

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      416196..420029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182575.1 → NP_013793.1  TPA: Pds5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013793.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZQ0, Q04264, Q04780
      UniProtKB/TrEMBL
      C7GL48
      Conserved Domains (2) summary
      sd00044
      Location:276 → 308
      HEAT; HEAT repeat [structural motif]
      cd19953
      Location:28 → 680
      PDS5; Sister chromatid cohesion protein PDS5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04264.1

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