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    Smr3b submaxillary gland androgen regulated protein 3B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24867, updated on 9-Dec-2024

    Summary

    Official Symbol
    Smr3bprovided by RGD
    Official Full Name
    submaxillary gland androgen regulated protein 3Bprovided by RGD
    Primary source
    RGD:3953
    See related
    EnsemblRapid:ENSRNOG00000001942 AllianceGenome:RGD:3953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arp; Smr1; Smr1g; Vcsa1; P2-VA1; RATSMR1A
    Summary
    Enables endopeptidase inhibitor activity. Involved in cellular response to lipopolysaccharide; negative regulation of peptidase activity; and regulation of sensory perception of pain. Located in extracellular region. Orthologous to human SMR3B (submaxillary gland androgen regulated protein 3B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 13.8), Spleen (RPKM 10.5) and 3 other tissues See more
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    Genomic context

    See Smr3b in Genome Data Viewer
    Location:
    14p22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (20067850..20072520, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (19783815..19788557, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (21490216..21709077, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene amelotin Neighboring gene opiorphin prepropeptide Neighboring gene U4 spliceosomal RNA Neighboring gene variable coding sequence A2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    SMR1 protein
    Names
    VCS-alpha 1
    Variable coding sequence A1 (androgen regulated protein (SMR1) gene)
    androgen regulated protein
    sialorphin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012684.4NP_036816.4  SMR1 protein precursor

      See identical proteins and their annotated locations for NP_036816.4

      Status: VALIDATED

      Source sequence(s)
      CB769246, JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P13432
      Related
      ENSRNOP00000073073.2, ENSRNOT00000087477.3
      Conserved Domains (1) summary
      pfam15621
      Location:1108
      PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      20067850..20072520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091622.2XP_038947550.1  SMR1 protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4K1, A6KKK3
      Conserved Domains (1) summary
      pfam15621
      Location:1108
      PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family