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    Hsph1 heat shock protein family H (Hsp110) member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288444, updated on 3-Dec-2024

    Summary

    Official Symbol
    Hsph1provided by RGD
    Official Full Name
    heat shock protein family H (Hsp110) member 1provided by RGD
    Primary source
    RGD:1311609
    See related
    EnsemblRapid:ENSRNOG00000000902 AllianceGenome:RGD:1311609
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hsp105
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity and alpha-tubulin binding activity. Predicted to be involved in protein folding. Predicted to act upstream of or within chaperone cofactor-dependent protein refolding. Predicted to be located in cytoplasm; microtubule; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleus. Orthologous to human HSPH1 (heat shock protein family H (Hsp110) member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 213.3), Kidney (RPKM 139.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Hsph1 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (10427368..10446602)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (5390916..5410224)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (6322685..6341898, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene beta 3-glucosyltransferase Neighboring gene small nucleolar RNA SNORA67 Neighboring gene uncharacterized LOC108352411 Neighboring gene WD40 repeat domain 95 Neighboring gene uncharacterized LOC120095877

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chaperone cofactor-dependent protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    heat shock protein 105 kDa
    Names
    heat shock 105/110 protein 1
    heat shock 105kDa
    heat shock 105kDa/110kDa protein 1
    heat shock 110 kDa protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011901.2NP_001011901.1  heat shock protein 105 kDa

      See identical proteins and their annotated locations for NP_001011901.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q66HA8
      UniProtKB/TrEMBL
      A0A8I6GLC4, A6K161
      Related
      ENSRNOP00000001201.6, ENSRNOT00000001201.9
      Conserved Domains (1) summary
      cd11739
      Location:2384
      HSPH1_NBD; Nucleotide-binding domain of HSPH1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      10427368..10446602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089153.2XP_038945081.1  heat shock protein 105 kDa isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXF4, A0A8I6GLC4
      Related
      ENSRNOP00000082622.1, ENSRNOT00000116960.2
      Conserved Domains (1) summary
      cd11739
      Location:2384
      HSPH1_NBD; Nucleotide-binding domain of HSPH1
    2. XM_063271115.1XP_063127185.1  heat shock protein 105 kDa isoform X2

      UniProtKB/TrEMBL
      A0A8I6AB23