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    Slc4a4 solute carrier family 4 member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84484, updated on 27-Nov-2024

    Summary

    Symbol
    Slc4a4provided by RGD
    Full Name
    solute carrier family 4 member 4provided by RGD
    Primary source
    RGD:68936
    See related
    EnsemblRapid:ENSRNOG00000003134 AllianceGenome:RGD:68936
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    KNBC; NBC2; Nbc1; Nbc4; PNBC; HHNMC; HNBC1; SLC4A5
    Summary
    Enables sodium:bicarbonate symporter activity. Involved in metanephric proximal tubule development. Located in membrane. Used to study nephrogenic diabetes insipidus. Biomarker of hypertension. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 1388.3), Brain (RPKM 248.9) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc4a4 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (19125394..19577379, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (18841289..19293297, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (20476258..20817042, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene GC, vitamin D binding protein Neighboring gene signal recognition particle 19, pseudogene 1 Neighboring gene gem-associated protein 8-like Neighboring gene deoxycytidine kinase Neighboring gene MOB kinase activator 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoatomic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sodium:bicarbonate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium:bicarbonate symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sodium:bicarbonate symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sodium:bicarbonate symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sodium:bicarbonate symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium:bicarbonate symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sodium:bicarbonate symporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables solute:inorganic anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within bicarbonate transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bicarbonate transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inorganic anion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in metanephric proximal tubule development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of positive regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of intracellular pH IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of regulation of intracellular pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of intracellular pH ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of pH TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sodium ion export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in basolateral plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    electrogenic sodium bicarbonate cotransporter 1
    Names
    NBC-like protein
    Na(+)/HCO3(-) cotransporter
    Na+HCO3- cotransporter 4
    sodium bicarbonate cotransporter
    solute carrier family 4 (anion exchanger), member 4
    solute carrier family 4, sodium bicarbonate cotransporter, member 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053424.1NP_445876.1  electrogenic sodium bicarbonate cotransporter 1

      See identical proteins and their annotated locations for NP_445876.1

      Status: PROVISIONAL

      Source sequence(s)
      AF254802
      UniProtKB/Swiss-Prot
      O35422, O54815, Q9JI66, Q9JJ32, Q9QXH6
      UniProtKB/TrEMBL
      A0A8I6ABC3, A6KKH6
      Related
      ENSRNOP00000035006.2, ENSRNOT00000033806.4
      Conserved Domains (3) summary
      TIGR00834
      Location:1091003
      ae; anion exchange protein
      pfam00955
      Location:436954
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:137387
      Band_3_cyto; Band 3 cytoplasmic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      19125394..19577379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092509.2XP_038948437.1  electrogenic sodium bicarbonate cotransporter 1 isoform X3

      UniProtKB/TrEMBL
      A0A0H2UHB7, A0A8I6AFE1
      Conserved Domains (1) summary
      TIGR00834
      Location:1141008
      ae; anion exchange protein
    2. XM_006250791.5XP_006250853.1  electrogenic sodium bicarbonate cotransporter 1 isoform X4

      See identical proteins and their annotated locations for XP_006250853.1

      UniProtKB/TrEMBL
      A0A0H2UHB7, A6KKH5
      Related
      ENSRNOP00000004391.5, ENSRNOT00000004391.5
      Conserved Domains (1) summary
      TIGR00834
      Location:1091003
      ae; anion exchange protein
    3. XM_039092511.2XP_038948439.1  electrogenic sodium bicarbonate cotransporter 1 isoform X4

      UniProtKB/TrEMBL
      A0A0H2UHB7, A6KKH5
      Conserved Domains (1) summary
      TIGR00834
      Location:1091003
      ae; anion exchange protein
    4. XM_039092507.1XP_038948435.1  electrogenic sodium bicarbonate cotransporter 1 isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHB7
      Conserved Domains (1) summary
      TIGR00834
      Location:1491043
      ae; anion exchange protein
    5. XM_039092508.2XP_038948436.1  electrogenic sodium bicarbonate cotransporter 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ABC3
      Related
      ENSRNOP00000092374.2, ENSRNOT00000101333.2
      Conserved Domains (1) summary
      TIGR00834
      Location:1491043
      ae; anion exchange protein