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    Grin3a glutamate ionotropic receptor NMDA type subunit 3A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 191573, updated on 27-Nov-2024

    Summary

    Official Symbol
    Grin3aprovided by RGD
    Official Full Name
    glutamate ionotropic receptor NMDA type subunit 3Aprovided by RGD
    Primary source
    RGD:621704
    See related
    EnsemblRapid:ENSRNOG00000005723 AllianceGenome:RGD:621704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NR3; chi-1; GluN3A
    Summary
    Enables glutamate-gated receptor activity; glycine binding activity; and protein phosphatase 2A binding activity. Contributes to NMDA glutamate receptor activity. Involved in several processes, including calcium ion transport; ionotropic glutamate receptor signaling pathway; and negative regulation of dendritic spine development. Located in cytoplasm and postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 52.7), Muscle (RPKM 4.6) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Grin3a in Genome Data Viewer
    Location:
    5q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (68802333..69001880, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (64006847..64206408, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (64928620..65073012, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134478968 Neighboring gene eukaryotic translation initiation factor 2 subunit alpha, pseudogene 1 Neighboring gene post-GPI attachment to proteins GalNAc transferase 4 Neighboring gene ring finger protein 20 Neighboring gene protein phosphatase 3, regulatory subunit B, beta Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134478969

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to NMDA glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to NMDA glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NMDA glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NMDA glutamate receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NMDA glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NMDA glutamate receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutamate-gated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutamate-gated receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables glycine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glycine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables glycine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase 2A binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmitter-gated monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendrite development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ionotropic glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ionotropic glutamate receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ionotropic glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of dendritic spine development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in prepulse inhibition IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within prepulse inhibition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic plasticity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rhythmic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of NMDA selective glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of NMDA selective glutamate receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of NMDA selective glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of monoatomic ion channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of neurotransmitter receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutamate receptor ionotropic, NMDA 3A
    Names
    N-methyl-D-aspartate receptor subtype 3A
    NMDAR-L
    NMDAR-L1
    NMDAR3A
    NR3 chi-1
    NR3A
    glutamate [NMDA] receptor subunit 3A
    glutamate receptor chi-1
    glutamate receptor, ionotropic, N-methyl-D-aspartate 3A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198583.2NP_001185512.1  glutamate receptor ionotropic, NMDA 3A isoform 2 precursor

      See identical proteins and their annotated locations for NP_001185512.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      BI294379, U29873
      UniProtKB/TrEMBL
      A6KJD4
      Conserved Domains (4) summary
      cd06377
      Location:30497
      PBP1_iGluR_NMDA_NR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family
      cd13720
      Location:512908
      PBP2_iGluR_NMDA_Nr3; The ligand-binding domain of the NR3 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:676942
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:127469
      ANF_receptor; Receptor family ligand binding region
    2. NM_138546.2NP_612555.1  glutamate receptor ionotropic, NMDA 3A isoform 1 precursor

      See identical proteins and their annotated locations for NP_612555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF073379, BI294379
      UniProtKB/Swiss-Prot
      O09098, O09155, Q62800, Q63268, Q9R1M7, Q9Z2H0
      UniProtKB/TrEMBL
      A6KJD3
      Conserved Domains (4) summary
      cd06377
      Location:30497
      PBP1_iGluR_NMDA_NR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family
      cd13720
      Location:512908
      PBP2_iGluR_NMDA_Nr3; The ligand-binding domain of the NR3 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:676942
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:127469
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      68802333..69001880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109241.2XP_038965169.1  glutamate receptor ionotropic, NMDA 3A isoform X1

      Related
      ENSRNOP00000007957.7, ENSRNOT00000007957.8
      Conserved Domains (3) summary
      cd13720
      Location:512908
      PBP2_iGluR_NMDA_Nr3; The ligand-binding domain of the NR3 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      cd06377
      Location:40496
      PBP1_iGluR_NMDA_NR3; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family
      pfam00060
      Location:676942
      Lig_chan; Ligand-gated ion channel