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    Ugcg UDP-glucose ceramide glucosyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83626, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ugcgprovided by RGD
    Official Full Name
    UDP-glucose ceramide glucosyltransferaseprovided by RGD
    Primary source
    RGD:621870
    See related
    EnsemblRapid:ENSRNOG00000015644 AllianceGenome:RGD:621870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ceramide glucosyltransferase activity. Predicted to be involved in several processes, including cornified envelope assembly; establishment of skin barrier; and glucosylceramide biosynthetic process. Located in Golgi membrane. Biomarker of hypertension. Orthologous to human UGCG (UDP-glucose ceramide glucosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 107.6), Spleen (RPKM 95.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ugcg in Genome Data Viewer
    Location:
    5q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (78828006..78860725)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (74032978..74065701)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (76376722..76419564)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene shortage in chiasmata 1 Neighboring gene uncharacterized LOC102550849 Neighboring gene uncharacterized LOC134478985 Neighboring gene uncharacterized LOC102551074 Neighboring gene sushi domain containing 1 Neighboring gene uncharacterized LOC134486940

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ceramide glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ceramide glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ceramide glucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cornified envelope assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cornified envelope assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of skin barrier ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of skin barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucosylceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glucosylceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucosylceramide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intestinal lipid absorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intestinal lipid absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in keratinocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in leptin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leptin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein lipidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein lipidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ceramide glucosyltransferase
    Names
    GCS
    GLCT-1
    UDP-glucose:N-acylsphingosine D-glucosyltransferase
    UDP-glucose:ceramide glycosyltransferase
    glucosylceramide synthase
    glycosylceramide synthase
    NP_113983.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031795.2NP_113983.1  ceramide glucosyltransferase

      See identical proteins and their annotated locations for NP_113983.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      O55149, Q9R0E0
      UniProtKB/TrEMBL
      A6KDW2
      Related
      ENSRNOP00000075148.1, ENSRNOT00000088872.3
      Conserved Domains (2) summary
      cd02520
      Location:51280
      Glucosylceramide_synthase; Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis
      pfam13641
      Location:51276
      Glyco_tranf_2_3; Glycosyltransferase like family 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      78828006..78860725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)