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    Dgkz diacylglycerol kinase zeta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81821, updated on 3-Dec-2024

    Summary

    Official Symbol
    Dgkzprovided by RGD
    Official Full Name
    diacylglycerol kinase zetaprovided by RGD
    Primary source
    RGD:70929
    See related
    EnsemblRapid:ENSRNOG00000017737 AllianceGenome:RGD:70929
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ATP-dependent diacylglycerol kinase activity. Predicted to be involved in several processes, including glycerolipid metabolic process; lipid phosphorylation; and maintenance of postsynaptic density structure. Predicted to act upstream of or within negative regulation of Ras protein signal transduction. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human DGKZ (diacylglycerol kinase zeta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 437.4), Brain (RPKM 234.6) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Dgkz in Genome Data Viewer
    Location:
    3q24
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (98359804..98401847, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77904149..77946114, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (80844002..80886487, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene autophagy and beclin 1 regulator 1 Neighboring gene uncharacterized LOC134486121 Neighboring gene cholinergic receptor, muscarinic 4 Neighboring gene ATP synthase membrane subunit c locus 1, pseudogene 1 Neighboring gene midkine Neighboring gene cAMP responsive element binding protein 3-like 1 Neighboring gene uncharacterized LOC103691847

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP-dependent diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables alkylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diacylglycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diacylglycerol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glycerolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glycerolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipid phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in maintenance of postsynaptic density structure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G1 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidic acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    diacylglycerol kinase zeta
    Names
    104 kDa diacylglycerol kinase
    DAG kinase zeta
    DGK-IV
    DGK-zeta
    diglyceride kinase zeta
    NP_001402081.1
    NP_112405.1
    XP_006234656.1
    XP_017447551.1
    XP_038961852.1
    XP_038961854.1
    XP_063140712.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415152.1NP_001402081.1  diacylglycerol kinase zeta isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K707, A0A8I6AMI5
      Related
      ENSRNOP00000074012.2, ENSRNOT00000091265.3
    2. NM_001429512.1NP_001416441.1  diacylglycerol kinase zeta isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A444, A6HNF2
    3. NM_001429513.1NP_001416442.1  diacylglycerol kinase zeta isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AMI5, A0A8I6GM44
    4. NM_031143.3NP_112405.1  diacylglycerol kinase zeta isoform 2

      See identical proteins and their annotated locations for NP_112405.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O08560
      UniProtKB/TrEMBL
      A0A8I6AMI5, A6HNF1
      Related
      ENSRNOP00000024280.2, ENSRNOT00000024280.6
      Conserved Domains (7) summary
      smart00045
      Location:447604
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:298419
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:294617
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00204
      Location:795911
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:795889
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:795821
      ANK; ANK repeat [structural motif]
      cl00040
      Location:173232
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      98359804..98401847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592062.3XP_017447551.1  diacylglycerol kinase zeta isoform X3

      Related
      ENSRNOP00000097565.1, ENSRNOT00000117598.2
    2. XM_039105926.2XP_038961854.1  diacylglycerol kinase zeta isoform X4

      UniProtKB/TrEMBL
      A0A8I6AMI5
      Conserved Domains (6) summary
      smart00045
      Location:327484
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:178299
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      sd00045
      Location:675701
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:675769
      Ank_2; Ankyrin repeats (3 copies)
      cd20895
      Location:51125
      C1_DGKzeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins
      cl00040
      Location:141
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    3. XM_006234594.5XP_006234656.1  diacylglycerol kinase zeta isoform X1

      Related
      ENSRNOP00000087400.1, ENSRNOT00000095998.2
      Conserved Domains (7) summary
      smart00045
      Location:639796
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:490611
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:486809
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00204
      Location:9871103
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:9871081
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:9871013
      ANK; ANK repeat [structural motif]
      cl00040
      Location:365424
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    4. XM_063284642.1XP_063140712.1  diacylglycerol kinase zeta isoform X1

      UniProtKB/TrEMBL
      A0A8I6A444, A6HNF2
    5. XM_039105924.2XP_038961852.1  diacylglycerol kinase zeta isoform X2

      Conserved Domains (4) summary
      smart00045
      Location:639796
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:490611
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd20849
      Location:280353
      C1_DGKzeta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins
      cd20895
      Location:363437
      C1_DGKzeta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase zeta (DAG kinase zeta) and similar proteins

    RNA

    1. XR_005501992.2 RNA Sequence