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    Nr0b2 nuclear receptor subfamily 0, group B, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117274, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nr0b2provided by RGD
    Official Full Name
    nuclear receptor subfamily 0, group B, member 2provided by RGD
    Primary source
    RGD:621032
    See related
    EnsemblRapid:ENSRNOG00000007229 AllianceGenome:RGD:621032
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Shp
    Summary
    Enables nuclear retinoid X receptor binding activity; nuclear thyroid hormone receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including bile acid and bile salt transport; negative regulation of transcription by RNA polymerase II; and positive regulation of insulin secretion. Part of protein-containing complex. Biomarker of alcoholic hepatitis; diabetes mellitus; and intrahepatic cholestasis. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR0B2 (nuclear receptor subfamily 0 group B member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 82.2), Heart (RPKM 54.3) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nr0b2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (151063160..151066475)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (145779294..145782609)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (151776004..151779319)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103102 Neighboring gene keratinocyte differentiation factor 1 Neighboring gene nuclear distribution C, dynein complex regulator Neighboring gene large ribosomal subunit protein uL29-like Neighboring gene G patch domain containing 3 Neighboring gene GPN-loop GTPase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear retinoic acid receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear retinoid X receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear thyroid hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables peroxisome proliferator activated receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription regulator inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in bile acid and bile salt transport IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear receptor subfamily 0 group B member 2
    Names
    orphan nuclear receptor SHP
    small heterodimer partner homologue

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057133.1NP_476474.1  nuclear receptor subfamily 0 group B member 2

      See identical proteins and their annotated locations for NP_476474.1

      Status: PROVISIONAL

      Source sequence(s)
      D86580
      UniProtKB/Swiss-Prot
      P97947
      UniProtKB/TrEMBL
      A6ISX4
      Related
      ENSRNOP00000009683.1, ENSRNOT00000009683.4
      Conserved Domains (1) summary
      cl11397
      Location:36257
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      151063160..151066475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)