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    Adrb2 adrenoceptor beta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24176, updated on 27-Nov-2024

    Summary

    Official Symbol
    Adrb2provided by RGD
    Official Full Name
    adrenoceptor beta 2provided by RGD
    Primary source
    RGD:2060
    See related
    EnsemblRapid:ENSRNOG00000019217 AllianceGenome:RGD:2060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including G-protein alpha-subunit binding activity; beta2-adrenergic receptor activity; and signaling receptor binding activity. Involved in several processes, including chemical synaptic transmission; diaphragm contraction; and positive regulation of monoatomic ion transport. Located in several cellular components, including caveola; neuronal cell body membrane; and sarcolemma. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic membrane. Used to study cardiomyopathy (multiple); congestive heart failure; kidney disease (multiple); and lung disease (multiple). Biomarker of several diseases, including acute kidney failure; artery disease (multiple); congestive heart failure; polycystic ovary syndrome; and ulcerative colitis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); disease of metabolism (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Orthologous to human ADRB2 (adrenoceptor beta 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
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    Genomic context

    See Adrb2 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (57912760..57914802, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (55642459..55644501, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (57513792..57515834, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene SH3 domain and tetratricopeptide repeats 2 Neighboring gene uncharacterized LOC120098151 Neighboring gene uncharacterized LOC102556293 Neighboring gene uncharacterized LOC108348797 Neighboring gene 5-hydroxytryptamine receptor 4

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables B2 bradykinin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables G-protein alpha-subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables PDZ domain binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables adenylate cyclase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenylate cyclase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta2-adrenergic receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables beta2-adrenergic receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta2-adrenergic receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta2-adrenergic receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables epinephrine binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables norepinephrine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables norepinephrine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables norepinephrine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 2A binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor-receptor interaction IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in AMPA selective glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in AMPA selective glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in associative learning IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in blood vessel diameter maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone resorption IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amyloid-beta IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in diaphragm contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in diet induced thermogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within diet induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in estrous cycle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in heat generation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within heat generation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in liver development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of urine volume IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ATP-dependent activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of autophagosome maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagosome maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of bone mineralization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cAMP/PKA signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cAMP/PKA signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of lipophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of lipophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lipophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mini excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mini excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of skeletal muscle tissue growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of the force of heart contraction by epinephrine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of systemic arterial blood pressure by norepinephrine-epinephrine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to catecholamine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to cold IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to cold ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to dexamethasone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to monoamine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to testosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vasodilation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in caveola TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal dense core vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuronal dense core vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    beta-2 adrenergic receptor
    Names
    Adrenergic beta 2- receptor surface
    adrenergic receptor, beta 2
    adrenergic, beta-2-, receptor, surface
    adrenoceptor beta 2, surface
    beta-2 adrenoceptor
    beta-2 adrenoreceptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012492.2NP_036624.2  beta-2 adrenergic receptor

      See identical proteins and their annotated locations for NP_036624.2

      Status: VALIDATED

      Source sequence(s)
      BC086538
      UniProtKB/Swiss-Prot
      P10608, Q6LCR3
      UniProtKB/TrEMBL
      D7NIV9, Q8VBU7
      Related
      ENSRNOP00000086275.2, ENSRNOT00000101212.2
      Conserved Domains (2) summary
      pfam00001
      Location:50326
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:48340
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      57912760..57914802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)