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    Dck deoxycytidine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79127, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dckprovided by RGD
    Official Full Name
    deoxycytidine kinaseprovided by RGD
    Primary source
    RGD:620667
    See related
    EnsemblRapid:ENSRNOG00000003296 AllianceGenome:RGD:620667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables deoxycytidine kinase activity; heterocyclic compound binding activity; and magnesium ion binding activity. Involved in deoxycytidine metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human DCK (deoxycytidine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 541.5), Spleen (RPKM 193.1) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Dck in Genome Data Viewer
    Location:
    14p22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (19589298..19610326, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (19305218..19326247, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (20935442..20952939, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene signal recognition particle 19, pseudogene 1 Neighboring gene solute carrier family 4 member 4 Neighboring gene gem-associated protein 8-like Neighboring gene MOB kinase activator 1B Neighboring gene G-rich RNA sequence binding factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytidine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables deoxyadenosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables deoxyadenosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables deoxycytidine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables deoxycytidine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables deoxycytidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables deoxycytidine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables deoxycytidine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables deoxyguanosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables deoxyguanosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables deoxyribonucleoside binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyrimidine deoxyribonucleoside binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pyrimidine deoxyribonucleoside binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in CMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dAMP salvage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dAMP salvage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in deoxycytidine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in deoxycytidine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleoside phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyrimidine nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyrimidine nucleotide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    deoxycytidine kinase
    Names
    deoxyadenosine kinase
    deoxyguanosine kinase
    NP_077072.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024158.2NP_077072.2  deoxycytidine kinase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      P48769
      UniProtKB/TrEMBL
      A6KKI1, G3V6E9
      Related
      ENSRNOP00000004440.5, ENSRNOT00000004440.9
      Conserved Domains (1) summary
      pfam01712
      Location:24258
      dNK; Deoxynucleoside kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      19589298..19610326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)