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    Gc GC, vitamin D binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24384, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gcprovided by RGD
    Official Full Name
    GC, vitamin D binding proteinprovided by RGD
    Primary source
    RGD:2667
    See related
    EnsemblRapid:ENSRNOG00000003119 AllianceGenome:RGD:2667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DBP; VDB; Vdbp; DBP02
    Summary
    Enables vitamin D binding activity. Involved in several processes, including female pregnancy; lactation; and response to estradiol. Located in axon; extracellular space; and perinuclear region of cytoplasm. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 38784.0) See more
    Orthologs
    NEW
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    Genomic context

    Location:
    14p22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (18916255..18951670)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (18632146..18667563)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (20267023..20302577)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1, motif 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene neuropeptide FF receptor 2 Neighboring gene signal recognition particle 19, pseudogene 1 Neighboring gene solute carrier family 4 member 4 Neighboring gene gem-associated protein 8-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcidiol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcidiol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables vitamin D binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables vitamin D binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables vitamin D binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables vitamin D binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables vitamin transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in lactation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in vitamin D metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vitamin D metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within vitamin D metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vitamin transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    vitamin D-binding protein
    Names
    gc-globulin
    group specific component
    NP_036696.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012564.3NP_036696.2  vitamin D-binding protein precursor

      See identical proteins and their annotated locations for NP_036696.2

      Status: VALIDATED

      Source sequence(s)
      BC078891
      UniProtKB/Swiss-Prot
      P04276
      UniProtKB/TrEMBL
      A6KKH1, F7FJ08, Q68FY4
      Related
      ENSRNOP00000004174.2, ENSRNOT00000004174.6
      Conserved Domains (2) summary
      smart00103
      Location:19201
      ALBUMIN; serum albumin
      pfam09164
      Location:405469
      VitD-bind_III; Vitamin D binding protein, domain III

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      18916255..18951670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)