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    Camk2a calcium/calmodulin-dependent protein kinase II alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25400, updated on 27-Nov-2024

    Summary

    Official Symbol
    Camk2aprovided by RGD
    Official Full Name
    calcium/calmodulin-dependent protein kinase II alphaprovided by RGD
    Primary source
    RGD:2261
    See related
    EnsemblRapid:ENSRNOG00000018712 AllianceGenome:RGD:2261
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PKCCD; PK2CDD
    Summary
    Enables GTPase activating protein binding activity and calcium/calmodulin-dependent protein kinase activity. Involved in several processes, including neurotransmitter receptor transport to plasma membrane; protein phosphorylation; and regulation of protein localization to cell periphery. Located in axon; dendrite cytoplasm; and neuronal cell body. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density; and presynaptic cytosol. Biomarker of middle cerebral artery infarction and transient cerebral ischemia. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 53 and autosomal recessive intellectual developmental disorder 63. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 681.4) and Muscle (RPKM 138.5) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Camk2a in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (56648779..56711505)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (54378642..54441120)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (56193978..56295869)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550733 Neighboring gene arylsulfatase family, member I Neighboring gene solute carrier family 6 member 7 Neighboring gene caudal type homeo box 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activating protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium/calmodulin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G1/S transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in angiotensin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiotensin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to interferon-beta IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interferon-beta ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to type II interferon IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendritic spine development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ionotropic glutamate receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neurotransmitter receptor transport to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endocannabinoid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endocannabinoid signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial membrane permeability involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuronal synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neurotransmitter secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of synaptic vesicle docking ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to ischemia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ischemia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of calcium- and calmodulin-dependent protein kinase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of calcium- and calmodulin-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of calcium- and calmodulin-dependent protein kinase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase type II subunit alpha
    Names
    Ca2+/calmodulin-dependent protein kinase II alpha
    alpha CaM kinase II
    caM kinase II subunit alpha
    caM-kinase II alpha chain
    caMK-II subunit alpha
    calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
    calcium/calmodulin-dependent protein kinase II alpha subunit
    calcium/calmodulin-dependent protein kinase type II alpha chain
    NP_037052.1
    XP_038952520.1
    XP_038952521.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012920.1NP_037052.1  calcium/calmodulin-dependent protein kinase type II subunit alpha

      See identical proteins and their annotated locations for NP_037052.1

      Status: PROVISIONAL

      Source sequence(s)
      J02942
      UniProtKB/Swiss-Prot
      P11275
      UniProtKB/TrEMBL
      A0A8I6AHE3, A6IXE8
      Conserved Domains (2) summary
      cd14086
      Location:11302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:346473
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      56648779..56711505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096592.2XP_038952520.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUV8, F1LZG4
      Related
      ENSRNOP00000093893.2, ENSRNOT00000101374.2
      Conserved Domains (2) summary
      cd14086
      Location:11302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:357484
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    2. XM_039096593.2XP_038952521.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A8I6AHE3
      Related
      ENSRNOP00000069249.2, ENSRNOT00000080177.3
      Conserved Domains (2) summary
      cd14086
      Location:11302
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:346473
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain