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    Camk4 calcium/calmodulin-dependent protein kinase IV [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25050, updated on 9-Dec-2024

    Summary

    Official Symbol
    Camk4provided by RGD
    Official Full Name
    calcium/calmodulin-dependent protein kinase IVprovided by RGD
    Primary source
    RGD:2264
    See related
    EnsemblRapid:ENSRNOG00000020478 AllianceGenome:RGD:2264
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdpk; RATCCDPK
    Summary
    Enables calcium/calmodulin-dependent protein kinase activity. Involved in protein phosphorylation. Is active in glutamatergic synapse and postsynapse. Biomarker of alcohol use disorder and withdrawal disorder. Human ortholog(s) of this gene implicated in cocaine dependence. Orthologous to human CAMK4 (calcium/calmodulin dependent protein kinase IV). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 286.0), Brain (RPKM 259.1) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Camk4 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (24857152..25076054)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (24582988..24811918)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (25746878..25975962)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 36 Neighboring gene uncharacterized LOC134482926 Neighboring gene uncharacterized LOC120098266 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482925 Neighboring gene StAR-related lipid transfer domain containing 4 Neighboring gene neuronal regeneration related protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium/calmodulin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term memory ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in myeloid dendritic cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myeloid dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myeloid dendritic cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within neuron-neuron synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in positive regulation of myeloid dendritic cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynapse to nucleus signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postsynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase type IV
    Names
    CAM kinase-GR
    Calmodulin-dependent protein kinase IV
    caMK IV
    calspermin
    NP_036859.2
    XP_006254585.3
    XP_038952502.1
    XP_063133166.1
    XP_063133167.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012727.3NP_036859.2  calcium/calmodulin-dependent protein kinase type IV

      See identical proteins and their annotated locations for NP_036859.2

      Status: PROVISIONAL

      Source sequence(s)
      BC128706
      UniProtKB/Swiss-Prot
      A1A5L5, P13234, Q63892
      UniProtKB/TrEMBL
      A6J2R5
      Related
      ENSRNOP00000027771.4, ENSRNOT00000027771.6
      Conserved Domains (1) summary
      cd14085
      Location:38331
      STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      24857152..25076054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254523.5XP_006254585.3  calcium/calmodulin-dependent protein kinase type IV isoform X2

      UniProtKB/TrEMBL
      A0A8L2UQP4, A6J2R2
    2. XM_063277096.1XP_063133166.1  calcium/calmodulin-dependent protein kinase type IV isoform X1

      UniProtKB/TrEMBL
      A6J2R3
      Related
      ENSRNOP00000072926.3, ENSRNOT00000078822.3
    3. XM_063277097.1XP_063133167.1  calcium/calmodulin-dependent protein kinase type IV isoform X4

    4. XM_039096574.2XP_038952502.1  calcium/calmodulin-dependent protein kinase type IV isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:43226
      PKc_like; Protein Kinases, catalytic domain