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    Ghrh growth hormone releasing hormone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29446, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ghrhprovided by RGD
    Official Full Name
    growth hormone releasing hormoneprovided by RGD
    Primary source
    RGD:61883
    See related
    EnsemblRapid:ENSRNOG00000007782 AllianceGenome:RGD:61883
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GHRF
    Summary
    Enables growth hormone-releasing hormone activity. Involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; positive regulation of cell communication; and positive regulation of circadian sleep/wake cycle, non-REM sleep. Located in axon terminus; extracellular space; and perikaryon. Used to study myocardial infarction and prostatic hypertrophy. Biomarker of sleep disorder. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome type 1; endometrial cancer; ovarian cancer; and renal cell carcinoma. Orthologous to human GHRH (growth hormone releasing hormone). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 1.8), Brain (RPKM 0.7) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Ghrh in Genome Data Viewer
    Location:
    3q42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (166412763..166432519, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (145992762..146012528, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (153449124..153468794, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486195 Neighboring gene maestro heat-like repeat family member 8 Neighboring gene uncharacterized LOC134486194 Neighboring gene ribophorin II Neighboring gene mannosidase beta like Neighboring gene uncharacterized LOC108350508

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables growth hormone-releasing hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth hormone-releasing hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables growth hormone-releasing hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth hormone-releasing hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth hormone-releasing hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within adenohypophysis development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenohypophysis development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to interleukin-6 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in growth hormone secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cAMP/PKA signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in positive regulation of circadian sleep/wake cycle, REM sleep ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of growth hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to dexamethasone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within response to food ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to leptin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in perikaryon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    somatoliberin
    Names
    GRF
    growth hormone-releasing factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031577.1NP_113765.1  somatoliberin precursor

      See identical proteins and their annotated locations for NP_113765.1

      Status: PROVISIONAL

      Source sequence(s)
      M73486
      UniProtKB/Swiss-Prot
      P09916
      UniProtKB/TrEMBL
      A6JWS0
      Related
      ENSRNOP00000010444.4, ENSRNOT00000010443.8
      Conserved Domains (1) summary
      pfam00123
      Location:3158
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      166412763..166432519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762304.2XP_008760526.1  somatoliberin isoform X1

      See identical proteins and their annotated locations for XP_008760526.1

      UniProtKB/Swiss-Prot
      P09916
      UniProtKB/TrEMBL
      A6JWS0
      Conserved Domains (1) summary
      pfam00123
      Location:3158
      Hormone_2; Peptide hormone
    2. XM_063283212.1XP_063139282.1  somatoliberin isoform X1

      UniProtKB/Swiss-Prot
      P09916
      UniProtKB/TrEMBL
      A6JWS0
    3. XM_063283213.1XP_063139283.1  somatoliberin isoform X1

      UniProtKB/Swiss-Prot
      P09916
      UniProtKB/TrEMBL
      A6JWS0