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    Slc6a7 solute carrier family 6 member 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117100, updated on 27-Nov-2024

    Summary

    Symbol
    Slc6a7provided by RGD
    Full Name
    solute carrier family 6 member 7provided by RGD
    Primary source
    RGD:620928
    See related
    EnsemblRapid:ENSRNOG00000018644 AllianceGenome:RGD:620928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prot
    Summary
    Enables L-proline transmembrane transporter activity and proline:sodium symporter activity. Involved in proline transport and protein catabolic process. Is active in several cellular components, including Schaffer collateral - CA1 synapse; presynaptic membrane; and synaptic vesicle membrane. Orthologous to human SLC6A7 (solute carrier family 6 member 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 93.0) and Testes (RPKM 14.0) See more
    Orthologs
    NEW
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    Genomic context

    See Slc6a7 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (56718849..56737702, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (54448464..54467319, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (56305765..56325179, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene arylsulfatase family, member I Neighboring gene calcium/calmodulin-dependent protein kinase II alpha Neighboring gene caudal type homeo box 1 Neighboring gene platelet derived growth factor receptor beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-proline transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-proline transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-proline transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables proline:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proline:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables proline:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables proline:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables proline:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in glycine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proline transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within proline transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proline transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proline transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proline transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proline transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein catabolic process EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sodium-dependent proline transporter
    Names
    L-proline transporter
    proline transporter
    sodium-dependent proline transporter-like
    solute carrier family 6 (neurotransmitter transporter), member 7
    solute carrier family 6 (neurotransmitter transporter, L-proline), member 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053996.2NP_446448.2  sodium-dependent proline transporter

      See identical proteins and their annotated locations for NP_446448.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018, M88111
      UniProtKB/Swiss-Prot
      P28573
      UniProtKB/TrEMBL
      A0A0G2JYB6, A6IXF3
      Related
      ENSRNOP00000070592.1, ENSRNOT00000085841.3
      Conserved Domains (1) summary
      cl00456
      Location:37581
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      56718849..56737702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)