Ctbs chitobiase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctbsprovided by RGD
Official Full Name: chitobiaseprovided by RGD
Primary source: RGD:621338
See related: EnsemblRapid:ENSRNOG00000015573 AllianceGenome:RGD:621338
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables chitinase activity. Involved in chitin catabolic process and oligosaccharide catabolic process. Predicted to be located in lysosome. Orthologous to human CTBS (chitobiase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 386.4), Thymus (RPKM 265.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (238000800..238015368)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (235340520..235355091)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (252305874..252320387)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AV266943 (e-PCR)
- UniSTS:178951

BE113911 (e-PCR)
- UniSTS:246844

BF403356 (e-PCR)
- UniSTS:246424

AI178777 (e-PCR)
- UniSTS:250567

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chitin binding	IEA Inferred from Electronic Annotation more info
enables chitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity, acting on glycosyl bonds	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in chitin catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in oligosaccharide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: di-N-acetylchitobiase

Names: chitobiase, di-N-acetyl-

NP_112285.1

EC 3.2.1.-

XP_038959139.1

EC 3.2.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031023.1 → NP_112285.1 di-N-acetylchitobiase precursor

See identical proteins and their annotated locations for NP_112285.1

Status: PROVISIONAL

Source sequence(s)

M95768

UniProtKB/Swiss-Prot

Q01460

UniProtKB/TrEMBL

A6HWD6, A6HWD7

Related

ENSRNOP00000020972.2, ENSRNOT00000020972.6

Conserved Domains (2) summary

cd02875
Location:23 → 363

GH18_chitobiase; Chitobiase (also known as di-N-acetylchitobiase) is a lysosomal glycosidase that hydrolyzes the reducing-end N-acetylglucosamine from the chitobiose core of oligosaccharides during the ordered degradation of asparagine-linked glycoproteins in eukaryotes. ...

smart00636
Location:100 → 343

Glyco_18; Glyco_18 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

238000800..238015368

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103211.2 → XP_038959139.1 di-N-acetylchitobiase isoform X1

Conserved Domains (1) summary

cl10447
Location:43 → 247

GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...