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    Src SRC proto-oncogene, non-receptor tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83805, updated on 9-Dec-2024

    Summary

    Official Symbol
    Srcprovided by RGD
    Official Full Name
    SRC proto-oncogene, non-receptor tyrosine kinaseprovided by RGD
    Primary source
    RGD:620795
    See related
    EnsemblRapid:ENSRNOG00000009495 AllianceGenome:RGD:620795
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including insulin receptor binding activity; nuclear estrogen receptor binding activity; and protein kinase C binding activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; cellular response to peptide hormone stimulus; and positive regulation of signal transduction. Located in several cellular components, including caveola; dendrite; and synaptic membrane. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Used to study Parkinsonism; brain ischemia; hypertension; status epilepticus; and type 2 diabetes mellitus. Biomarker of hepatocellular carcinoma and pancreatic acinar cell adenocarcinoma. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human SRC (SRC proto-oncogene, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 86.6), Lung (RPKM 78.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Src in Genome Data Viewer
    Location:
    3q42
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (166511616..166559463)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (146091969..146139492)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (153547807..153595643)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene mannosidase beta like Neighboring gene uncharacterized LOC108350508 Neighboring gene uncharacterized LOC134486197 Neighboring gene uncharacterized LOC134486196 Neighboring gene BLCAP, apoptosis inducing factor Neighboring gene neuronatin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables BMP receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables connexin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phospholipase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adherens junction organization IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in angiotensin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bone resorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell adhesion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to angiotensin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to peptide hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to platelet-derived growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to platelet-derived growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to progesterone stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to prolactin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to reactive oxygen species ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within forebrain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-6-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intestinal epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning or memory IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in myoblast proliferation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neutrophil activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurotrophin TRK receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within odontogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within oogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within osteoclast development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet-derived growth factor receptor signaling pathway IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lamellipodium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of male germ cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of outer hair cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of platelet-derived growth factor receptor-beta signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in primary ovarian follicle growth IMP
    Inferred from Mutant Phenotype
    more info
     
    involved_in progesterone receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in progesterone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of caveolin-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of cell projection assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of toll-like receptor 3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to acidic pH IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to mineralocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in skeletal muscle cell proliferation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within uterus development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic specialization, intracellular component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proto-oncogene tyrosine-protein kinase Src
    Names
    Rous sarcoma oncogene
    c-Src
    p60-Src
    pp60c-src
    proto-oncogene c-Src
    tyrosine protein kinase c-src
    tyrosine protein kinase pp60-c-src
    v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
    v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
    NP_114183.1
    XP_017447555.1
    XP_017447557.1
    XP_017447560.1
    XP_038961885.1
    XP_038961886.1
    XP_038961888.1
    XP_038961889.1
    XP_038961890.1
    XP_038961891.1
    XP_038961892.1
    XP_038961893.1
    XP_038961894.1
    XP_063140734.1
    XP_063140735.1
    XP_063140736.1
    XP_063140737.1
    XP_063140738.1
    XP_063140739.1
    XP_063140740.1
    XP_063140741.1
    XP_063140742.1
    XP_063140743.1
    XP_063140744.1
    XP_063140745.1
    XP_063140746.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431489.1NP_001418418.1  proto-oncogene tyrosine-protein kinase Src isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      G3V776, Q45QJ2, Q9JJ10, Q9WUD9
    2. NM_001431490.1NP_001418419.1  proto-oncogene tyrosine-protein kinase Src isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      G3V776, Q45QJ2, Q9JJ10, Q9WUD9
    3. NM_001431491.1NP_001418420.1  proto-oncogene tyrosine-protein kinase Src isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      G3V776, Q45QJ2, Q9JJ10, Q9WUD9
    4. NM_001431492.1NP_001418421.1  proto-oncogene tyrosine-protein kinase Src isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      G3V776, Q45QJ2, Q9JJ10, Q9WUD9
    5. NM_001431493.1NP_001418422.1  proto-oncogene tyrosine-protein kinase Src isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    6. NM_031977.2NP_114183.1  proto-oncogene tyrosine-protein kinase Src isoform b

      See identical proteins and their annotated locations for NP_114183.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q9WUD9
      Conserved Domains (3) summary
      cd10365
      Location:153253
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88149
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:266542
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      166511616..166559463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284671.1XP_063140741.1  proto-oncogene tyrosine-protein kinase Src isoform X2

    2. XM_039105966.2XP_038961894.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      Related
      ENSRNOP00000071837.2, ENSRNOT00000080516.3
      Conserved Domains (3) summary
      cd10365
      Location:147247
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88143
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:260536
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    3. XM_063284670.1XP_063140740.1  proto-oncogene tyrosine-protein kinase Src isoform X2

    4. XM_063284664.1XP_063140734.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    5. XM_039105962.2XP_038961890.1  proto-oncogene tyrosine-protein kinase Src isoform X1

      Conserved Domains (3) summary
      cd10365
      Location:153253
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88149
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:266542
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    6. XM_063284666.1XP_063140736.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    7. XM_063284665.1XP_063140735.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    8. XM_039105964.2XP_038961892.1  proto-oncogene tyrosine-protein kinase Src isoform X1

      Conserved Domains (3) summary
      cd10365
      Location:153253
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88149
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:266542
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    9. XM_017592066.3XP_017447555.1  proto-oncogene tyrosine-protein kinase Src isoform X1

      UniProtKB/Swiss-Prot
      Q9WUD9
      Conserved Domains (3) summary
      cd10365
      Location:153253
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88149
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:266542
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    10. XM_039105957.2XP_038961885.1  proto-oncogene tyrosine-protein kinase Src isoform X1

      Related
      ENSRNOP00000012739.3, ENSRNOT00000012739.6
      Conserved Domains (3) summary
      cd10365
      Location:153253
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88149
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:266542
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    11. XM_063284668.1XP_063140738.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      G3V776, Q45QJ2, Q9JJ10, Q9WUD9
    12. XM_063284667.1XP_063140737.1  proto-oncogene tyrosine-protein kinase Src isoform X1

    13. XM_063284676.1XP_063140746.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      G3V776, Q45QJ2, Q9JJ10, Q9WUD9
    14. XM_039105961.2XP_038961889.1  proto-oncogene tyrosine-protein kinase Src isoform X1

      Conserved Domains (3) summary
      cd10365
      Location:153253
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88149
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:266542
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    15. XM_063284672.1XP_063140742.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      G3V776, Q45QJ2, Q9JJ10, Q9WUD9
    16. XM_039105965.2XP_038961893.1  proto-oncogene tyrosine-protein kinase Src isoform X1

      Conserved Domains (3) summary
      cd10365
      Location:153253
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88149
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:266542
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    17. XM_063284674.1XP_063140744.1  proto-oncogene tyrosine-protein kinase Src isoform X2

    18. XM_017592068.3XP_017447557.1  proto-oncogene tyrosine-protein kinase Src isoform X1

      UniProtKB/Swiss-Prot
      Q9WUD9
      Conserved Domains (3) summary
      cd10365
      Location:153253
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88149
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:266542
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    19. XM_039105958.2XP_038961886.1  proto-oncogene tyrosine-protein kinase Src isoform X1

      Conserved Domains (3) summary
      cd10365
      Location:153253
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88149
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:266542
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    20. XM_039105960.2XP_038961888.1  proto-oncogene tyrosine-protein kinase Src isoform X1

      Conserved Domains (3) summary
      cd10365
      Location:153253
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88149
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:266542
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    21. XM_063284673.1XP_063140743.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      G3V776, Q45QJ2, Q9JJ10, Q9WUD9
    22. XM_063284669.1XP_063140739.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      G3V776, Q45QJ2, Q9JJ10, Q9WUD9
    23. XM_063284675.1XP_063140745.1  proto-oncogene tyrosine-protein kinase Src isoform X2

      UniProtKB/Swiss-Prot
      G3V776, Q45QJ2, Q9JJ10, Q9WUD9
    24. XM_017592071.3XP_017447560.1  proto-oncogene tyrosine-protein kinase Src isoform X1

      UniProtKB/Swiss-Prot
      Q9WUD9
      Conserved Domains (3) summary
      cd10365
      Location:153253
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88149
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:266542
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src
    25. XM_039105963.2XP_038961891.1  proto-oncogene tyrosine-protein kinase Src isoform X1

      Conserved Domains (3) summary
      cd10365
      Location:153253
      SH2_Src_Src; Src homology 2 (SH2) domain found in tyrosine kinase sarcoma (Src)
      cd12008
      Location:88149
      SH3_Src; Src homology 3 domain of Src Protein Tyrosine Kinase
      cd05071
      Location:266542
      PTKc_Src; Catalytic domain of the Protein Tyrosine Kinase, Src