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    Arhgap1 Rho GTPase activating protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311193, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arhgap1provided by RGD
    Official Full Name
    Rho GTPase activating protein 1provided by RGD
    Primary source
    RGD:1306068
    See related
    EnsemblRapid:ENSRNOG00000016610 AllianceGenome:RGD:1306068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including negative regulation of endocytic recycling; small GTPase-mediated signal transduction; and transferrin transport. Located in perinuclear region of cytoplasm. Orthologous to human ARHGAP1 (Rho GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 250.8), Heart (RPKM 143.3) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Arhgap1 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (98077064..98099163)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (77621377..77643400)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (80555196..80576881)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cytoskeleton associated protein 5 Neighboring gene transfer RNA alanine (anticodon AGC) 76 Neighboring gene coagulation factor II, thrombin Neighboring gene zinc finger protein 408 Neighboring gene autophagy related 13 Neighboring gene harbinger transposase derived 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within small GTPase-mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transferrin transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sorting endosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107747.2NP_001101217.2  rho GTPase-activating protein 1

      Status: VALIDATED

      Source sequence(s)
      AA900696, CK480577, CO573331, DN932805, DV725096, EV768858
      UniProtKB/TrEMBL
      A0A8I6A7T6, D4A6C5
      Conserved Domains (2) summary
      cd04404
      Location:239431
      RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
      pfam13716
      Location:82216
      CRAL_TRIO_2; Divergent CRAL/TRIO domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      98077064..98099163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104900.2XP_038960828.1  rho GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7T6, D4A6C5
      Conserved Domains (2) summary
      cd04404
      Location:239431
      RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
      pfam13716
      Location:82216
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    2. XM_006234551.4XP_006234613.1  rho GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7T6, D4A6C5
      Related
      ENSRNOP00000059324.1, ENSRNOT00000067318.5
      Conserved Domains (2) summary
      cd04404
      Location:239431
      RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
      pfam13716
      Location:82216
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    3. XM_006234560.4XP_006234622.1  rho GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7T6, D4A6C5
      Related
      ENSRNOP00000070761.3, ENSRNOT00000079118.3
      Conserved Domains (2) summary
      cd04404
      Location:239431
      RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
      pfam13716
      Location:82216
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    4. XM_006234556.4XP_006234618.1  rho GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7T6, D4A6C5
      Conserved Domains (2) summary
      cd04404
      Location:239431
      RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
      pfam13716
      Location:82216
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    5. XM_039104901.2XP_038960829.1  rho GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7T6, D4A6C5
      Conserved Domains (2) summary
      cd04404
      Location:239431
      RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
      pfam13716
      Location:82216
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    6. XM_006234554.4XP_006234616.1  rho GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7T6, D4A6C5
      Conserved Domains (2) summary
      cd04404
      Location:239431
      RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
      pfam13716
      Location:82216
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    7. XM_006234558.5XP_006234620.1  rho GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7T6, D4A6C5
      Conserved Domains (2) summary
      cd04404
      Location:239431
      RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
      pfam13716
      Location:82216
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    8. XM_006234552.5XP_006234614.1  rho GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7T6, D4A6C5
      Conserved Domains (2) summary
      cd04404
      Location:239431
      RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
      pfam13716
      Location:82216
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    9. XM_006234557.5XP_006234619.1  rho GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7T6, D4A6C5
      Conserved Domains (2) summary
      cd04404
      Location:239431
      RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
      pfam13716
      Location:82216
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    10. XM_017591716.3XP_017447205.1  rho GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7T6, D4A6C5
      Conserved Domains (2) summary
      cd04404
      Location:239431
      RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
      pfam13716
      Location:82216
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    11. XM_006234553.5XP_006234615.1  rho GTPase-activating protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7T6, D4A6C5
      Conserved Domains (2) summary
      cd04404
      Location:239431
      RhoGAP-p50rhoGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4, ...
      pfam13716
      Location:82216
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
    12. XM_006234559.4XP_006234621.1  rho GTPase-activating protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7T6
      Conserved Domains (2) summary
      cd04404
      Location:165357
      RhoGAP-p50rhoGAP; RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol ...
      pfam13716
      Location:8132
      CRAL_TRIO_2; Divergent CRAL/TRIO domain