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    Itga8 integrin subunit alpha 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364786, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itga8provided by RGD
    Official Full Name
    integrin subunit alpha 8provided by RGD
    Primary source
    RGD:621634
    See related
    EnsemblRapid:ENSRNOG00000016538 AllianceGenome:RGD:621634
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564327
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; integrin-mediated signaling pathway; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within several processes, including inner ear morphogenesis; memory; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in dendritic spine membrane and perikaryon. Is active in glutamatergic synapse and postsynaptic density membrane. Biomarker of mesangial proliferative glomerulonephritis. Human ortholog(s) of this gene implicated in end stage renal disease; ovarian cancer; renal agenesis; and schizophrenia. Orthologous to human ITGA8 (integrin subunit alpha 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 569.1), Heart (RPKM 121.2) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Itga8 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (80213139..80410633, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (75304004..75501510, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (79321893..79676927, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene N-myristoyltransferase 2 Neighboring gene family with sequence similarity 171, member A1 Neighboring gene uncharacterized LOC134482749 Neighboring gene uncharacterized LOC134482750 Neighboring gene uncharacterized LOC120097958 Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC103694135 Neighboring gene MINDY lysine 48 deubiquitinase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell projection organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inner ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mesodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within metanephros development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in smooth muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    integrin alpha-8
    Names
    integrin, alpha 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173972.1NP_001167443.1  integrin alpha-8

      See identical proteins and their annotated locations for NP_001167443.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168655
      UniProtKB/TrEMBL
      B5DEG1, F7F1E3
      Related
      ENSRNOP00000022713.5, ENSRNOT00000022711.6
      Conserved Domains (3) summary
      smart00191
      Location:382436
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam00357
      Location:10341048
      Integrin_alpha; Integrin alpha cytoplasmic region
      pfam08441
      Location:482933
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      80213139..80410633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)