Cfp complement factor properdin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cfpprovided by RGD
Official Full Name: complement factor properdinprovided by RGD
Primary source: RGD:1594557
See related: EnsemblRapid:ENSRNOG00000025811 AllianceGenome:RGD:1594557
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pfc
Summary: Predicted to be involved in complement activation, alternative pathway. Predicted to be located in cytoplasmic side of Golgi membrane; extracellular space; and secretory granule. Human ortholog(s) of this gene implicated in X-linked properdin deficiency. Orthologous to human CFP (complement factor properdin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 1392.2), Liver (RPKM 224.7) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (3715551..3721113)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (1162014..1167576)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (1311121..1316683)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
Title: Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
tubular HS as a novel docking platform for alternative pathway activation via properdin, which might play a role in proteinuric renal damage.
Title: Identification of tubular heparan sulfate as a docking platform for the alternative complement component properdin in proteinuric renal disease.

Submit: New GeneRIF Correction

General gene information

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Markers

RH141135 (e-PCR)
- UniSTS:223131

DXWox21 (e-PCR)
- UniSTS:517811

Cfp (e-PCR), detects polymorphism
- UniSTS:532667

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in complement activation, alternative pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic side of Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: properdin

Names: Properdin P factor, complement; properdin factor, complement

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.